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AB256053

Recombinant Human IL-20 protein

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Recombinant Human IL-20 protein is a Human Full Length protein, in the 25 to 176 aa range, expressed in Escherichia coli, with >95%, <1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

ZCYTO10, UNQ852/PRO1801, IL20, Interleukin-20, IL-20, Cytokine Zcyto10

1 Images
SDS-PAGE - Recombinant Human IL-20 protein (AB256053)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human IL-20 protein (AB256053)

SDS-PAGE analysis of ab256053 (1μg) under non-reducing (Lane

  1. and reducing (Lane 2) conditions.

4-20% Tris-Glycine gel. Coomassie Blue staining.

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

<1 EU/µg

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NYY1

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute at 0.1 mg/mL in water

Storage buffer

Constituents: 0.16% Sodium phosphate, 0.12% Sodium chloride

storage-buffer

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Complementary Products

Primary Antibodies

AB188200

Anti-IGFBP2 antibody [EPR18012-257]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-IGFBP2 antibody [EPR18012-257] (AB188200)

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Primary Antibodies

AB153940

Anti-MRPS27 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPS27 antibody (AB153940)

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Assay Kits

AB231927

Human IL-20 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human IL-20 ELISA Kit (AB231927)

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Primary Antibodies

AB244989

Anti-IL-20 antibody [EPR20756-205] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-IL-20 antibody [EPR20756-205] - BSA and Azide free (Detector) (AB244989)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"MLKTLNLGSCVIATNLQEIRNGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEETE","proteinLength":"Full Length","predictedMolecularWeight":"17.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":176,"aminoAcidStart":25,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NYY1","tags":[]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
False
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General info

Function

Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation (PubMed : 17277128, PubMed : 34403503). Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity (PubMed : 17277128). Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration (PubMed : 28424238). Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB (PubMed : 11706020). Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB (PubMed : 11564763). Acts as an arteriogenic and vascular remodeling factory by activating a range of signaling processes including phosphorylations of JAK2 and STAT5 as well as activation of the serine and threonine kinases AKT and ERK1/2 (By similarity). Alternatively, can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2 and p38 MAPK-dependent manner in keratinocytes (PubMed : 23614738).

Sequence similarities

Belongs to the IL-10 family.

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Product protocols

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Target data

Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation (PubMed : 17277128, PubMed : 34403503). Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity (PubMed : 17277128). Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration (PubMed : 28424238). Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB (PubMed : 11706020). Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB (PubMed : 11564763). Acts as an arteriogenic and vascular remodeling factory by activating a range of signaling processes including phosphorylations of JAK2 and STAT5 as well as activation of the serine and threonine kinases AKT and ERK1/2 (By similarity). Alternatively, can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2 and p38 MAPK-dependent manner in keratinocytes (PubMed : 23614738).
See full target information IL20
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Product promise

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