JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB269176

Recombinant human IL-21 protein (Active)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant human IL-21 protein (Active) is a Human Fragment protein, in the 32 to 162 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

View Alternative Names

Interleukin-21, IL-21, Za11, IL21

2 Images
Functional Studies - Recombinant human IL-21 protein (Active) (AB269176)
  • FuncS

Unknown

Functional Studies - Recombinant human IL-21 protein (Active) (AB269176)

Biological activity graph of ab269176

SDS-PAGE - Recombinant human IL-21 protein (Active) (AB269176)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant human IL-21 protein (Active) (AB269176)

SDS-PAGE analysis of ab269176 at 1ug/lane under (-) non-reducing and (+) reducing conditions. 4-20% Tris glycine gel. Stained with coomassie blue.

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE, FuncS

applications

Biologically active

Yes

Biological activity

ANBL-6 cell proliferation OR B9 cell proliferation ED50 ≤ 2 ng/mL; ≥ 5.0 x 10^5 units/mg (typical ED50 is < 1 ng/mL) OR ED50 ≤ 50 ng/mL; ≥ 2.0 x 10^4 units/mg.

Accession

Q9HBE4

Animal free

No

Carrier free

Yes

Species

Human

Reconstitution

Reconstitute at 0.1 mg/mL in water

Storage buffer

Constituents: 0.16% Sodium phosphate

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS","proteinLength":"Fragment","predictedMolecularWeight":"17 kDa","actualMolecularWeight":null,"aminoAcidEnd":162,"aminoAcidStart":32,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9HBE4","tags":[]}]
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Working aliquots stored with a carrier protein are stable for at least 3 months at -20°C to -80°C.
True
style
left-column
style
left-column

Specifications

Form

Lyophilized

Additional notes

nan

style
left-column

General info

Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed : 11081504, PubMed : 15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).

Sequence similarities

Belongs to the IL-15/IL-21 family.

style
left-column

Product protocols

style
left-column

Target data

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed : 11081504, PubMed : 15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
See full target information IL21
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB259403

Recombinant human IL-15 protein (Active)

Premium Bioactive

Functional Studies - Recombinant human IL-15 protein (Active) (AB259403)

  • 0
  • 0
Proteins & Peptides

AB259382

Recombinant human IL-7 protein (Active)

Premium Bioactive

Mass Spectrometry - Recombinant human IL-7 protein (Active) (AB259382)

  • 0
  • 0
Proteins & Peptides

AB283447

Recombinant human IL-1RA protein (Active)

Premium Bioactive

Functional Studies - Recombinant human IL-1RA protein (Active) (AB283447)

  • 0
  • 0
Proteins & Peptides

AB259380

Recombinant mouse IL-2 protein (Active)

Premium Bioactive

Functional Studies - Recombinant mouse IL-2 protein (Active) (AB259380)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com