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AB235875

Recombinant human IL-21 protein (His tag)

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Recombinant human IL-21 protein (His tag) is a Human Full Length protein, in the 23 to 155 aa range, expressed in Baculovirus infected insect cells, with >85%, < 1 EU/µL endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Interleukin-21, IL-21, Za11, IL21

1 Images
SDS-PAGE - Recombinant human IL-21 protein (His tag) (AB235875)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human IL-21 protein (His tag) (AB235875)

15% SDS-PAGE analysis of 3 μg ab235875.

18-28 kDa (Reducing conditions).

Key facts

Purity

>85% SDS-PAGE

Endotoxin level

< 1 EU/µL

Expression system

Baculovirus infected insect cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

Yes

Biological activity

The activity is determined by the IFN-g ELISA in a using NK-92 cell. The ED50 range ≤ 10 ng/ml.

Accession

Q9HBE4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 20% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>18-28kDa (SDS-PAGE under reducing conditions)</p>" } } }
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Sequence info

[{"sequence":"ADPEFMQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDSHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"16.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":155,"aminoAcidStart":23,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"Q9HBE4","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Specifications

Form

Liquid

Additional notes

ab235875 was expressed in insect cell and affinity purified.

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General info

Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed : 11081504, PubMed : 15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).

Sequence similarities

Belongs to the IL-15/IL-21 family.

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Product protocols

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Target data

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed : 11081504, PubMed : 15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
See full target information IL21
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