Recombinant human IL-22 protein (Active)
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Recombinant human IL-22 protein (Active) is a Human Full Length protein, in the 34 to 179 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS, Mass Spec, HPLC, Cell Culture.
View Alternative Names
ILTIF, ZCYTO18, UNQ3099/PRO10096, IL22, Interleukin-22, IL-22, Cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor, IL-TIF
- FuncS
Supplier Data
Functional Studies - Recombinant human IL-22 protein (Active) (AB280331)
Functional analysis of ab280331.
Fully biologically active determined by the dose dependent induction of IL-10 secretion in COLO-205 cells.
ED50 is 390 pg/ml.
Cell based assay testing is performed on the first lot of protein only and is provided as a reference for protein activity; subsequent lots of protein must pass all biophysical quality control parameters that meet the same parameters as the first lot.
Lot : GR3377996-1
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant human IL-22 protein (Active) (AB280331)
Mass determination by ESI-TOF.
Predicted MW is 16806.39 Da (+/- 10 Da by ESI-TOF). Observed MW is 16809.33
- HPLC
Supplier Data
HPLC - Recombinant human IL-22 protein (Active) (AB280331)
HPLC analysis of ab280331.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human IL-22 protein (Active) (AB280331)
SDS-PAGE analysis of ab280331.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Specifications
Form
Lyophilized
Additional notes
=95% Purity by HPLC
General info
Function
Cytokine that plays a critical role in modulating tissue responses during inflammation (PubMed : 17204547). Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage (PubMed : 17204547). Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB (PubMed : 10875937, PubMed : 18599299). Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways (PubMed : 25793261, PubMed : 31311100). Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN (By similarity). Promotes epithelial cell spreading (By similarity).
Sequence similarities
Belongs to the IL-10 family.
Target data
Complementary Products
Product promise
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