Skip to main content

Recombinant Human IL-24 protein (Fc Chimera) is a Human Full Length protein, in the 53 to 207 aa range, expressed in CHO, with >=98% purity, < 0.06 EU/µg endotoxin level and suitable for SDS-PAGE.

Be the first to review this product! Submit a review

Key facts

Purity

>=98% SDS-PAGE

Endotoxin level

< 0.06 EU/µg

Expression system

CHO cells

Tags

Tag free

Applications

SDS-PAGE

Biologically active

No

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).

Alternative names

Recommended products

Recombinant Human IL-24 protein (Fc Chimera) is a Human Full Length protein, in the 53 to 207 aa range, expressed in CHO, with >=98% purity, < 0.06 EU/µg endotoxin level and suitable for SDS-PAGE.

Key facts

Purity

>=98% SDS-PAGE

Endotoxin level

< 0.06 EU/µg

Expression system

CHO cells

Applications

SDS-PAGE

Accession
Q13007-1
Animal free

No

Species

Human

Reconstitution

Reconstitute at 100µg/ml in sterile PBS.

Concentration
Loading...
Storage buffer

Constituents: 100% PBS

Sequence info

Amino acid sequence

Accession

Q13007

Protein length

Full Length

Amino acids

53 to 207

Nature

Recombinant

Specifications

Form

Lyophilized

General info

Function

Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).

Sequence similarities

Belongs to the IL-10 family.

Post-translational modifications

Glycosylated.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle, Stable for 12 months at -20°C

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

0 product images

    Downloads

    Product protocols

    For this product, it's our understanding that no specific protocols are required. You can:

    Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

    For licensing inquiries, please contact partnerships@abcam.com