Recombinant Human IL-24 protein (Fc Chimera) is a Human Full Length protein, in the 53 to 207 aa range, expressed in CHO, with >=98% purity, < 0.06 EU/µg endotoxin level and suitable for SDS-PAGE.
>=98% SDS-PAGE
< 0.06 EU/µg
CHO cells
Tag free
SDS-PAGE
No
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).
MDA7, ST16, MDA7, IL24, ST16, Interleukin-24, IL-24, Melanoma differentiation-associated gene 7 protein, Suppression of tumorigenicity 16 protein, MDA-7
Recombinant Human IL-24 protein (Fc Chimera) is a Human Full Length protein, in the 53 to 207 aa range, expressed in CHO, with >=98% purity, < 0.06 EU/µg endotoxin level and suitable for SDS-PAGE.
>=98% SDS-PAGE
< 0.06 EU/µg
CHO cells
Tag free
SDS-PAGE
No
No
Human
Reconstitute at 100µg/ml in sterile PBS.
Constituents: 100% PBS
Full Length
53 to 207
Recombinant
Lyophilized
Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).
Belongs to the IL-10 family.
Glycosylated.
Blue Ice
1-2 weeks
+4°C
-20°C
Avoid freeze / thaw cycle, Stable for 12 months at -20°C
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