Recombinant Human IL-24 protein (Fc Chimera)
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Recombinant Human IL-24 protein (Fc Chimera) is a Human Full Length protein, in the 53 to 207 aa range, expressed in CHO cells, with >98%, < 0.06 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
MDA7, ST16, IL24, Interleukin-24, IL-24, Melanoma differentiation-associated gene 7 protein, Suppression of tumorigenicity 16 protein, MDA-7
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Specifications
Form
Lyophilized
General info
Function
Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed : 25168428, PubMed : 27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed : 27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed : 11706020, PubMed : 30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed : 25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).
Sequence similarities
Belongs to the IL-10 family.
Post-translational modifications
Glycosylated.. Ubiquitination at Lys-122 promotes proteasomal degradation.
Target data
Complementary Products
Product promise
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