JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB310793

Recombinant Human IL-24 Protein (His tag)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human IL-24 Protein (His tag) is a Human Fragment protein, in the 52 to 206 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC, Mass Spec.

View Alternative Names

MDA7, ST16, IL24, Interleukin-24, IL-24, Melanoma differentiation-associated gene 7 protein, Suppression of tumorigenicity 16 protein, MDA-7

2 Images
SDS-PAGE - Recombinant Human IL-24 Protein (His tag) (AB310793)
  • SDS-PAGE

Lab

SDS-PAGE - Recombinant Human IL-24 Protein (His tag) (AB310793)

SDS-PAGE analysis of ab310793

HPLC - Recombinant Human IL-24 Protein (His tag) (AB310793)
  • HPLC

Supplier Data

HPLC - Recombinant Human IL-24 Protein (His tag) (AB310793)

HPLC analysis of ab310793

Key facts

Purity

>95% HPLC

Endotoxin level

<0.005 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

Mass Spec, HPLC, SDS-PAGE

applications

Biologically active

No

Accession

Q13007

Animal free

Yes

Carrier free

No

Species

Human

Reconstitution

Lyophilized contents may appear as either a translucent film or a white powder. This variance does not affect the quality of the product. Store lyophilized form at room temperature. Reconstitute in phosphate buffered saline, aliquot and store at -80°C for 12 months or +4°C for 1 week. Avoid repeated freeze-thaw.

Storage buffer

pH: 7.4 Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic

storage-buffer

style
left-column

Complementary Products

Reagents, Controls & Accessories

AB234617

Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa) (AB234617)

  • 0
  • 0
Proteins & Peptides

AB271791

Recombinant Human VSIG8 protein (Fc tag C-Terminus + Avi tag C-Terminus)

SDS-PAGE - Recombinant Human VSIG8 protein (Fc tag C-Terminus + Avi tag C-Terminus) (AB271791)

  • 0
  • 0
Primary Antibodies

AB115207

Anti-IL-24 antibody

Flow Cytometry (Intracellular) - Anti-IL-24 antibody (AB115207)

  • 0
  • 0
Proteins & Peptides

AB307487

Recombinant Human TNFAIP3 Protein

Mass Spectrometry - Recombinant Human TNFAIP3 Protein (AB307487)

  • 0
  • 0
Proteins & Peptides

AB319985

Recombinant Mouse Prealbumin Protein Standard (His tag)

Sandwich ELISA - Recombinant Mouse Prealbumin Protein Standard (His tag) (AB319985)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"QEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL","proteinLength":"Fragment","predictedMolecularWeight":"19.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":206,"aminoAcidStart":52,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q13007","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
False
style
left-column
style
left-column

Specifications

Form

Lyophilized

Additional notes

SDS-PAGE>=95%

style
left-column

General info

Function

Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed : 25168428, PubMed : 27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed : 27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed : 11706020, PubMed : 30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed : 25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).

Sequence similarities

Belongs to the IL-10 family.

Post-translational modifications

Glycosylated.. Ubiquitination at Lys-122 promotes proteasomal degradation.

style
left-column

Product protocols

style
left-column

Target data

Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed : 25168428, PubMed : 27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed : 27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed : 11706020, PubMed : 30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed : 25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).
See full target information IL24
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com