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AB283936

Recombinant Human IL-31 protein (Active)

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Recombinant Human IL-31 protein (Active) is a Human Full Length protein, in the 27 to 164 aa range, expressed in HEK 293 cells, with >95%, < 0.005 EU/µg endotoxin level, suitable for SDS-PAGE, Mass Spec, HPLC, Cell Culture, FuncS.

View Alternative Names

Interleukin-31, IL-31, IL31

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Biological Activity - Recombinant Human IL-31 protein (Active) (AB283936)
  • Biological Activity

Supplier Data

Biological Activity - Recombinant Human IL-31 protein (Active) (AB283936)

Fully biologically active determined by its ability to induce STAT3 activation (phosphorylation Tyr705) in U-87 MG cells. ED50 is ≤ 25.9 ng/ml, corresponding to a specific activity of 3.86 x 104 units/mg.

Mass Spectrometry - Recombinant Human IL-31 protein (Active) (AB283936)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Human IL-31 protein (Active) (AB283936)

ESI TOF analysis of ab288936.

Predicted MW is 15569.82 Da (+/- 10 Da by ESI TOF). Observed MW is 15571.44 Da.

HPLC - Recombinant Human IL-31 protein (Active) (AB283936)
  • HPLC

Supplier Data

HPLC - Recombinant Human IL-31 protein (Active) (AB283936)

HPLC analysis of ab288936.

SDS-PAGE - Recombinant Human IL-31 protein (Active) (AB283936)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human IL-31 protein (Active) (AB283936)

SDS-PAGE analysis of ab288936.

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 0.005 EU/µg

Expression system

HEK 293 cells

Tags

Tag free

Applications

HPLC, FuncS, Mass Spec, Cell Culture, SDS-PAGE

applications

Biologically active

Yes

Biological activity

Fully biologically active determined by its ability to induce STAT3 activation (phosphorylation Tyr705) in U-87 MG cells.

ED50 is ≤ 25.9 ng/ml, corresponding to a specific activity of 3.86 x 104 units/mg.

Accession

Q6EBC2

Animal free

Yes

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Cell Culture": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"LPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT","proteinLength":"Full Length","predictedMolecularWeight":"15.57 kDa","actualMolecularWeight":"15.57 kDa","aminoAcidEnd":164,"aminoAcidStart":27,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q6EBC2","tags":[]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
True
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Specifications

Form

Lyophilized

Additional notes

Purity by HPLC =95%

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General info

Function

Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed : 15184896). May function in skin immunity (PubMed : 15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).

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Product protocols

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Target data

Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed : 15184896). May function in skin immunity (PubMed : 15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).
See full target information IL31
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