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AB276287

Recombinant human IL-3RB protein (His tag)

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Recombinant human IL-3RB protein (His tag) is a Human Fragment protein, in the 1 to 443 aa range, expressed in HEK 293 cells, with >97%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

View Alternative Names

CD131, IL3RB, IL5RB, CSF2RB, Cytokine receptor common subunit beta, CDw131, GM-CSF/IL-3/IL-5 receptor common beta subunit

2 Images
Functional Studies - Recombinant human IL-3RB protein (His tag) (AB276287)
  • FuncS

Supplier Data

Functional Studies - Recombinant human IL-3RB protein (His tag) (AB276287)

Measured by its binding ability in a functional ELISA.

Immobilized human CD131 at 10 μg/ml (100 μl/well) can bind human Fc-GMCSF.

The EC50Â of human Fc-GMCSF is 250-500 ng/ml.

Measured by its binding ability in a functional ELISA.#Immobilized human CD131 at 10 μg/ml (100 μl/well) can bind human Fc-GMCSF.#The EC50 of human Fc-GMCSF is 250-500 ng/ml.

SDS-PAGE - Recombinant human IL-3RB protein (His tag) (AB276287)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant human IL-3RB protein (His tag) (AB276287)

SDS-PAGE analysis of ab276287

Key facts

Purity

>97% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

Measured by its binding ability in a functional ELISA.

Immobilized human CD131 at 10 μg/ml (100 μl/well) can bind human Fc-GMCSF.

The EC50 of human Fc-GMCSF is 250-500 ng/ml.

Accession

P32927

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Primary Antibodies

AB86743

Anti-IL-3RB antibody [RM0112-42A7]

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Secondary Antibodies

AB99817

Mouse Anti-Human IgG4 pFc’ [HP6023] (HRP)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MVLAQGLLSMALLALCWERSLAGAEETIPLQTLRCYNDYTSHITCRWADTQDAQRLVNVTLIRRVNEDLLEPVSCDLSDDMPWSACPHPRCVPRRCVIPCQSFVVTDVDYFSFQPDRPLGTRLTVTLTQHVQPPEPRDLQISTDQDHFLLTWSVALGSPQSHWLSPGDLEFEVVYKRLQDSWEDAAILLSNTSQATLGPEHLMPSSTYVARVRTRLAPGSRLSGRPSKWSPEVCWDSQPGDEAQPQNLECFFDGAAVLSCSWEVRKEVASSVSFGLFYKPSPDAGEEECSPVLREGLGSLHTRHHCQIPVPDPATHGQYIVSVQPRRAEKHIKSSVNIQMAPPSLNVTKDGDSYSLRWETMKMRYEHIDHTFEIQYRKDTATWKDSKTETLQNAHSMALPALEPSTRYWARVRVRTSRTGYNGIWSEWSEARSWDTESVLPMW","proteinLength":"Fragment","predictedMolecularWeight":"50 kDa","actualMolecularWeight":null,"aminoAcidEnd":443,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P32927","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Specifications

Form

Lyophilized

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General info

Function

Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed : 1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed : 9516124).

Sequence similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Post-translational modifications

May be phosphorylated by LYN.

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Product protocols

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Target data

Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed : 1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed : 9516124).
See full target information CSF2RB
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Product promise

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