Recombinant Human ILT-7 protein is a Human Full Length protein, in the 1 to 499 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M T L I L T S L L F F G L S L G P R T R V Q A E N L P K P I L W A E P G P V I T W H N P V T I W C Q G T L E A Q G Y R L D K E G N S M S R H I L K T L E S E N K V K L S I P S M M W E H A G R Y H C Y Y Q S P A G W S E P S D P L E L V V T A Y S R P T L S A L P S P V V T S G V N V T L R C A S R L G L G R F T L I E E G D H R L S W T L N S H Q H N H G K F Q A L F P M G P L T F S N R G T F R C Y G Y E N N T P Y V W S E P S D P L Q L L V S G V S R K P S L L T L Q G P V V T P G E N L T L Q C G S D V G Y I R Y T L Y K E G A D G L P Q R P G R Q P Q A G L S Q A N F T L S P V S R S Y G G Q Y R C Y G A H N V S S E W S A P S D P L D I L I A G Q I S D R P S L S V Q P G P T V T S G E K V T L L C Q S W D P M F T F L L T K E G A A H P P L R L R S M Y G A H K Y Q A E F P M S P V T S A H A G T Y R C Y G S R S S N P Y L L S H P S E P L E L V V S G A T E T L N P A Q K K S D S K T A P H L Q D Y T V E N L I R M G V A G L V L L F L G I L L F E A Q H S Q R S P P R C S Q E A N S R K D N A P F R V V E P W E Q I
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760).
Alternative names
CD85g, ILT7, LILRA4, Leukocyte immunoglobulin-like receptor subfamily A member 4, CD85 antigen-like family member G, Immunoglobulin-like transcript 7, ILT-7
Recommended products
Recombinant Human ILT-7 protein is a Human Full Length protein, in the 1 to 499 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- P59901-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M T L I L T S L L F F G L S L G P R T R V Q A E N L P K P I L W A E P G P V I T W H N P V T I W C Q G T L E A Q G Y R L D K E G N S M S R H I L K T L E S E N K V K L S I P S M M W E H A G R Y H C Y Y Q S P A G W S E P S D P L E L V V T A Y S R P T L S A L P S P V V T S G V N V T L R C A S R L G L G R F T L I E E G D H R L S W T L N S H Q H N H G K F Q A L F P M G P L T F S N R G T F R C Y G Y E N N T P Y V W S E P S D P L Q L L V S G V S R K P S L L T L Q G P V V T P G E N L T L Q C G S D V G Y I R Y T L Y K E G A D G L P Q R P G R Q P Q A G L S Q A N F T L S P V S R S Y G G Q Y R C Y G A H N V S S E W S A P S D P L D I L I A G Q I S D R P S L S V Q P G P T V T S G E K V T L L C Q S W D P M F T F L L T K E G A A H P P L R L R S M Y G A H K Y Q A E F P M S P V T S A H A G T Y R C Y G S R S S N P Y L L S H P S E P L E L V V S G A T E T L N P A Q K K S D S K T A P H L Q D Y T V E N L I R M G V A G L V L L F L G I L L F E A Q H S Q R S P P R C S Q E A N S R K D N A P F R V V E P W E Q I
- Accession
- P59901
- Protein length
- Full Length
- Amino acids
- 1 to 499
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760).
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as LILRA4.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ILT-7 also known as LILRA4 is an important receptor involved in the immune response. It is expressed on plasmacytoid dendritic cells and holds significant weight approximately 38 kDa. The receptor is part of the immunoglobulin-like transcript family containing unique extracellular domains that interact with specific ligands. ILT-7 is known for its role in mediating signals that shape the behavior of immune cells particularly in antiviral defenses.
- Biological function summary
ILT-7 plays an important role in the regulation of type I interferon production in dendritic cells. This receptor forms a complex with the Fc epsilon RI gamma chain which transmits activation signals inside the cell. In resting conditions ILT-7 helps maintain immune homeostasis by regulating the release of interferons therefore balancing immune activation and controlling potential overactivity that might lead to autoimmunity.
- Pathways
ILT-7 interacts within the signaling network of toll-like receptor (TLR) pathways. It closely ties with TLR9 a protein that recognizes unmethylated CpG motifs often found in viral DNA enhancing the production of interferons during viral infections. This collaboration establishes a link between pathogen recognition and immune response modulation within dendritic cells assisting in orchestrating a potent defense against viral pathogens.
- Associated diseases and disorders
ILT-7 has connections to systemic lupus erythematosus and chronic viral infections. Dysregulation of ILT-7 expression or function can lead to excessive interferon production contributing to the pathology of lupus. In chronic viral infections ILT-7 interaction with proteins like TLR9 and the subsequent dysregulation can support viral persistence or worsen disease outcomes by altering immune responses. Understanding ILT-7’s roles offers insights into therapeutic targets for modulating immune response in these diseases.
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1 product image
SDS-PAGE - Recombinant Human ILT-7 protein (ab161681)
ab161681 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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