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AB276712

Recombinant Human ILT-7 protein (His tag)

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Recombinant Human ILT-7 protein (His tag) is a Human Fragment protein, in the 1 to 446 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

CD85g, ILT7, LILRA4, Leukocyte immunoglobulin-like receptor subfamily A member 4, CD85 antigen-like family member G, Immunoglobulin-like transcript 7, ILT-7

1 Images
SDS-PAGE - Recombinant Human ILT-7 protein (His tag) (AB276712)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ILT-7 protein (His tag) (AB276712)

SDS-PAGE analysis of ab276712

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P59901

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MTPILTVLICLGLSLGPRTRVQAENLPKPILWAEPGPVITWHNPVTIWCQGTLEAQGYRLDKEGNSMSRHILKTLESENKVKLSIPSMMWEHAGRYHCYYQSPAGWSEPSDPLELVVTAYSRPTLSALPSPVVTSGVNVTLRCASRLGLGRFTLIEEGDHRLSWTLNSHQHNHGKFQALFPMGPLTFSNRGTFRCYGYENNTPYVWSEPSDPLQLLVSGVSRKPSLLTLQGPVVTPGENLTLQCGSDVGYIRYTLYKEGADGLPQRPGRQPQAGLSQANFTLSPVSRSYGGQYRCYGAHNVSSEWSAPSDPLDILIAGQISDRPSLSVQPGPTVTSGEKVTLLCQSWDPMFTFLLTKEGAAHPPLRLRSMYGAHKYQAEFPMSPVTSAHAGTYRCYGTRSSNPYLLSHPSEPLELVVSGATETLNPAQKKSDSKTAPHLQDYTVEN","proteinLength":"Fragment","predictedMolecularWeight":"48.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":446,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P59901","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ILT-7 also known as LILRA4 is an important receptor involved in the immune response. It is expressed on plasmacytoid dendritic cells and holds significant weight approximately 38 kDa. The receptor is part of the immunoglobulin-like transcript family containing unique extracellular domains that interact with specific ligands. ILT-7 is known for its role in mediating signals that shape the behavior of immune cells particularly in antiviral defenses.
Biological function summary

ILT-7 plays an important role in the regulation of type I interferon production in dendritic cells. This receptor forms a complex with the Fc epsilon RI gamma chain which transmits activation signals inside the cell. In resting conditions ILT-7 helps maintain immune homeostasis by regulating the release of interferons therefore balancing immune activation and controlling potential overactivity that might lead to autoimmunity.

Pathways

ILT-7 interacts within the signaling network of toll-like receptor (TLR) pathways. It closely ties with TLR9 a protein that recognizes unmethylated CpG motifs often found in viral DNA enhancing the production of interferons during viral infections. This collaboration establishes a link between pathogen recognition and immune response modulation within dendritic cells assisting in orchestrating a potent defense against viral pathogens.

ILT-7 has connections to systemic lupus erythematosus and chronic viral infections. Dysregulation of ILT-7 expression or function can lead to excessive interferon production contributing to the pathology of lupus. In chronic viral infections ILT-7 interaction with proteins like TLR9 and the subsequent dysregulation can support viral persistence or worsen disease outcomes by altering immune responses. Understanding ILT-7’s roles offers insights into therapeutic targets for modulating immune response in these diseases.
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Specifications

Form

Lyophilized

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General info

Function

Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed : 16735691, PubMed : 19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades (PubMed : 16735691, PubMed : 19564354, PubMed : 24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed : 26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed : 16735691, PubMed : 19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed : 24586760).

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Product protocols

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Target data

Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed : 16735691, PubMed : 19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades (PubMed : 16735691, PubMed : 19564354, PubMed : 24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed : 26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed : 16735691, PubMed : 19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed : 24586760).
See full target information LILRA4
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