Recombinant Human IMMP2L protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IMMP2L also known as inner mitochondrial membrane peptidase subunit 2 processes polypeptides within mitochondria. It belongs to the peptidase M28 family and possesses a molecular mass of approximately 36 kDa. IMMP2L is expressed primarily in the mitochondria where it localizes to the inner mitochondrial membrane. Here it performs its enzymatic functions releasing various signaling peptides from their precursors which is important for mitochondrial operations.

Biological function summary

IMMP2L plays a role in the maturation of proteins by cleaving signal peptides in the mitochondrial intermembrane space. It forms part of a complex with another protein IMMP1L and works in concert to ensure proper processing of substrates like apoptosis-inducing factor (AIF) and Smac/Diablo which are critical for cellular homeostasis. The precise cleavage of these peptides allows for the correct arrangement and functioning within mitochondrial compartments.

Pathways

IMMP2L operates within the mitochondrial apoptosis pathway and is important for the regulation of cell death. It indirectly influences the intrinsic apoptotic pathway by facilitating the release of signaling molecules that activate downstream components such as caspases. This protein interacts closely with cytochrome c and AIF both essential for apoptosis initiation and regulation influencing cellular life-death decisions.

Research links IMMP2L to neurodevelopmental disorders particularly attention-deficit/hyperactivity disorder (ADHD). Mutations or dysfunctions in this gene can disrupt normal neuronal development possibly by affecting apoptosis during brain formation. Additionally IMMP2L alterations might contribute to a genetic susceptibility for Tourette syndrome where it connects with proteins like SLITRK1 altering neuropsychiatric development and function.