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AB104020

Recombinant Human IMPA2 protein

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Recombinant Human IMPA2 protein is a Human Full Length protein, in the 1 to 288 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

IMP.18P, IMPA2, Inositol monophosphatase 2, IMP 2, IMPase 2, Inositol-1(or 4)-monophosphatase 2, Myo-inositol monophosphatase A2

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SDS-PAGE - Recombinant Human IMPA2 protein (AB104020)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human IMPA2 protein (AB104020)

15% SDS-PAGE analysis of ab104020 (3 μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

O14732

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0308% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMKPSGEDQAALAAGPWEECFQAAVQLALRAGQIIRKALTEEKRVSTKTSAADLVTETDHLVEDLIISELRERFPSHRFIAEEAAASGAKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSIGFAVRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTEIGPKRDPATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYYQFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMACRVVAASTREMAMLIAQALQTINYGRDDEK","proteinLength":"Full Length","predictedMolecularWeight":"33.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":288,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O14732","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IMPA2 also known as Inositol Monophosphatase 2 is an enzyme with a mass of approximately 29 kDa. This protein is expressed predominantly in the brain particularly in regions such as the cerebellum and cerebral cortex. IMPA2 catalyzes the dephosphorylation of inositol monophosphate to free inositol an essential step in the phosphatidylinositol signaling pathway. This enzyme plays a significant role in maintaining inositol and inositol-derived compounds important for cellular functions.
Biological function summary

IMPA2 influences cellular processes by managing inositol phosphate recycling and inositol availability. This enzyme does not typically function as part of a larger protein complex. Its activity helps control the levels of inositol in cells impacting signaling pathways that rely on phosphatidylinositol and its derivatives. Through this regulation IMPA2 supports functions like cell growth and survival indirectly affecting neurotransmission and hormone signaling.

Pathways

IMPA2 assumes a central role in the phosphatidylinositol signaling pathway which influences a variety of cellular responses. It interacts closely with the phosphoinositide pathway sharing a relationship with proteins like G-protein coupled receptors and protein kinase C. The enzyme's activity ensures the continuous functioning of these pathways by supplying inositol an important molecule that these proteins need for activation and signaling transmission.

Researchers have linked IMPA2 to bipolar disorder and schizophrenia. Reduced or altered activity of IMPA2 might contribute to imbalance in inositol signaling which is a hypothesis in the pathophysiology of these psychiatric conditions. The protein shows connections to other molecules involved in these disorders such as glycogen synthase kinase-3 (GSK3) which plays a role in mood regulation and neuroplasticity. Understanding the role of IMPA2 in these diseases could offer insights into potential therapeutic approaches.
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Specifications

Form

Liquid

Additional notes

Purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.

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General info

Function

Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.

Sequence similarities

Belongs to the inositol monophosphatase superfamily.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.
See full target information IMPA2
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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