Products
Sample Prep & Detection Kits
Conjugation kitsPurification kitsSample preparation kitsChromogen kitsIHC kitsChIP kitsAccessory Reagents & Controls
Accessory reagents & controlsBiochemicals
BiochemicalsProteins and Peptides
Proteins and peptidesOur latest ELISA kit: Human Tau (phospho T217) - Intracellular
Highly sensitive kit offering the most promising biomarkers for Alzheimer’s disease diagnostics. Learn about all product ranges with our product overviews.
Resources
Featured events
Make new connections at our global events.
Support
Our programs
New Lab Program
Get a head start with our exclusive new lab discount. Enjoy 20% off and free shipping for three months.
New Biotech Program
Just starting out? Get 15% off and free shipping to your lab for six months.
Product promise
Peace of mind that all products perform as stated.
Product reviews
Leave reviews, get rewarded and help your community.
Trial program
Try untested species and applications to earn money off your next order.
Recombinant Human Indoleamine 2, 3-dioxygenase protein is a Human Full Length protein, in the 1 to 403 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Alternative names=IDO-1, INDO, IDO, IDO1
- Purity
>90% SDS-PAGE
- Expression system
Escherichia coli
- Tags
His tag N-Terminus
- Applications
SDS-PAGE, MS
- Biologically active
No
- Sequence
M G S S H H H H H H S S G L V P R G S H M G S M A H A M E N S W T I S K E Y H I D E E V G F A L P N P Q E N L P D F Y N D W M F I A K H L P D L I E S G Q L R E R V E K L N M L S I D H L T D H K S Q R L A R L V L G C I T M A Y V W G K G H G D V R K V L P R N I A V P Y C Q L S K K L E L P P I L V Y A D C V L A N W K K K D P N K P L T Y E N M D V L F S F R D G D C S K G F F L V S L L V E I A A A S A I K V I P T V F K A M Q M Q E R D T L L K A L L E I A S C L E K A L Q V F H Q I H D H V N P K A F F S V L R I Y L S G W K G N P Q L S D G L V Y E G F W E D P K E F A G G S A G Q S S V F Q C F D V L L G I Q Q T A G G G H A A Q F L Q D M R R Y M P P A H R N F L C S L E S N P S V R E F V L S K G D A G L R E A Y D A C V K A L V S L R S Y H L Q I V T K Y I L I P A S Q Q P K E N K T S E D P S K L E A K G T G G T D L M N F L K T V R S T T E K S L L K E G
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Images
Recommended products
Recombinant Human Indoleamine 2, 3-dioxygenase protein is a Human Full Length protein, in the 1 to 403 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Alternative names=IDO-1, INDO, IDO, IDO1
Key facts
- Purity
>90% SDS-PAGE
- Expression system
Escherichia coli
- Tags
His tag N-Terminus
- Applications
SDS-PAGE, MS
- Biologically active
No
- Predicted molecular weight
47.7 kDa
- Amino acids
1 to 403
- Sequence
M G S S H H H H H H S S G L V P R G S H M G S M A H A M E N S W T I S K E Y H I D E E V G F A L P N P Q E N L P D F Y N D W M F I A K H L P D L I E S G Q L R E R V E K L N M L S I D H L T D H K S Q R L A R L V L G C I T M A Y V W G K G H G D V R K V L P R N I A V P Y C Q L S K K L E L P P I L V Y A D C V L A N W K K K D P N K P L T Y E N M D V L F S F R D G D C S K G F F L V S L L V E I A A A S A I K V I P T V F K A M Q M Q E R D T L L K A L L E I A S C L E K A L Q V F H Q I H D H V N P K A F F S V L R I Y L S G W K G N P Q L S D G L V Y E G F W E D P K E F A G G S A G Q S S V F Q C F D V L L G I Q Q T A G G G H A A Q F L Q D M R R Y M P P A H R N F L C S L E S N P S V R E F V L S K G D A G L R E A Y D A C V K A L V S L R S Y H L Q I V T K Y I L I P A S Q Q P K E N K T S E D P S K L E A K G T G G T D L M N F L K T V R S T T E K S L L K E G
- Accession
- P14902-1
- Protein length
Full Length
- Animal free
No
- Nature
Recombinant
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Specifications
- Form
Liquid
- Additional notes
ab181930 was purified using conventional chromatography techniques.
General info
- Function
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885).
- Sequence similarities
Belongs to the indoleamine 2,3-dioxygenase family.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com