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AB187464

Recombinant Human ING1 protein (denatured) (His tag N-Terminus)

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Recombinant Human ING1 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 279 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

Inhibitor of growth protein 1, ING1

1 Images
SDS-PAGE - Recombinant Human ING1 protein (denatured) (His tag N-Terminus) (AB187464)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ING1 protein (denatured) (His tag N-Terminus) (AB187464)

15% SDS-PAGE analysis of ab187464 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UK53

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMLSPANGEQLHLVNYVEDYLDSIESLPFDLQRNVSLMREIDAKYQEILKELDECYERFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIVSQMVELVENRTRQVDSHVELFEAQQELGDTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDHDDGASGTPKEKKAKTSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSKKERAYNR","proteinLength":"Full Length","predictedMolecularWeight":"34.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":279,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UK53","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target ING1 also known as Inhibitor of Growth Protein 1 is a tumor suppressor protein with a mass of approximately 33 kDa. It functions mechanically by interacting with chromatin and transcriptional machinery to regulate cell growth apoptosis and DNA repair. ING1 localizes both in the nucleus and cytoplasm showing expression in various tissues but particularly in those with high proliferation rates.
Biological function summary

As part of the chromatin remodeling complex ING1 contributes to the regulation of gene expression by promoting histone acetylation. It affects the cellular response to stress and helps maintain genomic stability. Through interactions with other proteins in the complex ING1 influences cell cycle checkpoints and can induce apoptosis when DNA damage is irreparable.

Pathways

Several important cellular signaling cascades involve ING1. Notably it plays a role in the p53 signaling pathway where it collaborates with the tumor protein p53 to enhance transcriptional activation of downstream genes associated with growth arrest and apoptosis. Additionally ING1 participates in the PI3K/AKT pathway influencing cell survival and metabolism by modulating PI3K-mediated phosphorylation events.

Studies indicate that ING1 has significant links to cancer such as breast and colorectal cancer. Loss or mutation of ING1 disrupts its tumor suppressive functions leading to unchecked cellular proliferation. Moreover its interaction with the protein TP53 highlights its relevance in tumorigenesis as disruptions can impair p53-mediated tumor suppressive pathways further contributing to cancer development.
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Specifications

Form

Liquid

Additional notes

ab187464 was purified by using conventional chromatography techniques

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General info

Function

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Sequence similarities

Belongs to the ING family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
See full target information ING1
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