AB151344

Recombinant Human INHBC protein

Name: Recombinant Human INHBC protein (ab151344) | Abcam
Brand: Abcam Limited
SKU: AB151344
Price: 290 USD
Availability: InStock

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Recombinant Human INHBC protein is a Human Fragment protein, in the 237 to 352 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

Inhibin beta C chain, Activin beta-C chain, INHBC

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Applications

SDS-PAGE, HPLC

applications

Biologically active

Accession

P55103

Animal free

Carrier free

Species

Human

Reconstitution

Reconstitute in PBS

Storage buffer

Constituents: 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.01% Hydrochloric acid

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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Product details

This product was previously labelled as Inhibin beta C chain

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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGIDCQGGSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANTAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS","proteinLength":"Fragment","predictedMolecularWeight":"14.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":352,"aminoAcidStart":237,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P55103","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

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Properties and storage information

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle|Reconstitute for long term storage

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

INHBC also known as Inhibin Beta C is a protein known for its role in various cellular processes. It has a molecular mass of approximately 42 kDa. This protein expresses in a variety of tissues including liver testis and ovary. INHBC belongs to the transforming growth factor-beta (TGF-beta) superfamily known for its involvement in cell growth and differentiation.

Biological function summary

INHBC functions as part of the Inhibin/Activin complex that regulates follicle-stimulating hormone (FSH) secretion. Activin which INHBC is a subunit of plays a role in reproductive processes and cellular differentiation. This protein actively participates in modulating processes related to gonadal functions and embryogenesis. Its activity impacts cell proliferation anti-inflammatory responses and wound healing.

Pathways

INHBC interplays within the TGF-beta signaling pathway an important pathway controlling cellular proliferation and differentiation. It relates closely to Inhibin Alpha and Activin A within these pathways. These interactions with related proteins allow it to influence reproductive and cellular growth processes and maintain regulatory balances in physiology.

INHBC correlates with conditions such as reproductive system disorders and certain cancers. Its overexpression or dysregulation can link to ovarian cancer through its association with Activin A. Research suggests that alterations in INHBC levels may influence pathological conditions by disturbing normal growth factor signaling emphasizing its role in disease progression.

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Specifications

Form

Lyophilized

Additional notes

Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE

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General info

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Sequence similarities

Belongs to the TGF-beta family.

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Product protocols

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Inhibin beta C chain

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Recombinant Human INHBC protein

Key facts

Purity

Endotoxin level

Expression system

Tags

Applications

Biologically active

Accession

Animal free

Carrier free

Species

Reconstitution

Storage buffer

Reactivity data

Product details

Sequence info

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Specifications

Form

Additional notes

General info

Function

Sequence similarities

Product protocols

Target data

Complementary Products

Primary Antibodies

Proteins & Peptides

Primary Antibodies

Assay Kits

Product promise