Recombinant Human Inhibin beta E chain protein (Fc Chimera) is a Human Full Length protein, in the 237 to 350 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
>90% SDS-PAGE
- Endotoxin level
< 1 EU/µg
- Expression system
HEK 293 cells
- Tags
Fc tag N-Terminus
- Applications
SDS-PAGE
- Biologically active
No
Amino acid sequence
T P T C E P A T P L C C R R D H Y V D F Q E L G W R D W I L Q P E G Y Q L N Y C S G Q C P P H L A G S P G I A A S F H S A V F S L L K A N N P W P A S T S C C V P T A R R P L S L L Y L D H N G N V V K T D V P D M V V E A C G C S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Alternative names
Inhibin beta E chain, Activin beta-E chain, INHBE
Recommended products
Recombinant Human Inhibin beta E chain protein (Fc Chimera) is a Human Full Length protein, in the 237 to 350 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
>90% SDS-PAGE
- Endotoxin level
< 1 EU/µg
- Expression system
HEK 293 cells
- Tags
Fc tag N-Terminus
- Applications
SDS-PAGE
- Biologically active
No
- Accession
- P58166-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
T P T C E P A T P L C C R R D H Y V D F Q E L G W R D W I L Q P E G Y Q L N Y C S G Q C P P H L A G S P G I A A S F H S A V F S L L K A N N P W P A S T S C C V P T A R R P L S L L Y L D H N G N V V K T D V P D M V V E A C G C S
- Accession
- Protein length
Full Length
- Predicted molecular weight
40.9 kDa
- Amino acids
237 to 350
- Nature
Recombinant
- Tags
Fc tag N-Terminus
Specifications
- Form
Lyophilized
General info
- Function
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
- Sequence similarities
Belongs to the TGF-beta family.
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Inhibin beta E chain also known as 'INHBE' is a protein with multiple roles in the human body weighing about 42 kDa. It is a member of the transforming growth factor-beta (TGF-β) superfamily. The protein can be expressed in many tissues including the liver and placenta. INHBE is associated with other proteins to form different complexes affecting various biological processes.
- Biological function summary
The Inhibin beta E chain participates in the regulation of reproductive hormone activity. It forms either homodimers or heterodimers combining with other inhibin and activin molecules. The dimerization with alpha chains forms inhibins while pairing with other beta subunits forms activins. These complexes then modulate signaling pathways that adjust hormonal secretion particularly in the pituitary and gonadal tissues.
- Pathways
Inhibin beta E chain plays a significant role in the activin signaling pathway. This pathway affects the regulation of FSH (follicle-stimulating hormone) secretion which is important for reproductive processes. INHBE relates to proteins such as follistatin and activin A within these pathways influencing activities flowing from ligand-receptor interactions to transcriptional regulation.
- Associated diseases and disorders
Inhibin beta E chain has been linked to certain reproductive and metabolic disorders. For instance abnormal expression or dysfunction of INHBE may relate to polycystic ovary syndrome (PCOS) affecting women’s fertility. Liver diseases such as non-alcoholic fatty liver disease (NAFLD) also show associations with INHBE levels. In these contexts INHBE interacts with various TGF-β family proteins contributing to either disease progression or regulation.
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1 product image
SDS-PAGE - Recombinant Human Inhibin beta E chain protein (Fc Chimera) (ab276297)
SDS-PAGE analysis of ab276297
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