Recombinant Human INSL4 protein (His tag) is a Human Full Length protein, in the 1 to 139 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M A S L F R S Y L P A I W L L L S Q L L R E S L A A E L R G C G P R F G K H L L S Y C P M P E K T F T T T P G G W L L E S G R P K E M V S T S N N K D G Q A L G T T S E F I P N L S P E L K K P L S E G Q P S L K K I I L S R K K R S G R H R F D P F C C E V I C D D G T S V K L C T
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May play an important role in trophoblast development and in the regulation of bone formation.
Alternative names
Early placenta insulin-like peptide, EPIL, Insulin-like peptide 4, Placentin, INSL4
Recommended products
Recombinant Human INSL4 protein (His tag) is a Human Full Length protein, in the 1 to 139 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q14641-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M A S L F R S Y L P A I W L L L S Q L L R E S L A A E L R G C G P R F G K H L L S Y C P M P E K T F T T T P G G W L L E S G R P K E M V S T S N N K D G Q A L G T T S E F I P N L S P E L K K P L S E G Q P S L K K I I L S R K K R S G R H R F D P F C C E V I C D D G T S V K L C T
- Accession
- Q14641
- Protein length
- Full Length
- Predicted molecular weight
- 14 kDa
- Amino acids
- 1 to 139
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
May play an important role in trophoblast development and in the regulation of bone formation.
- Sequence similarities
Belongs to the insulin family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
INSL4 also known as insulin-like 4 is a protein with a mass of approximately 15.8 kDa. This protein originates within the insulin superfamily and functions mechanically by playing a role in cell signaling. INSL4 exhibits expression mainly in placenta-related tissues suggesting its involvement in pregnancy-related processes. It differs from other insulin-like peptides in terms of both its sequence and specific roles in reproduction.
- Biological function summary
INSL4 takes part in regulating placental development and can influence trophoblast differentiation. This protein operates independently rather than as a component of larger protein complexes. In early pregnancy INSL4 contributes to fetal tissue formation and influences cellular growth and differentiation. This makes INSL4 an important marker and functional molecule in embryonic development contexts.
- Pathways
INSL4 joins several critical signaling cascades related to cell growth and differentiation. The protein is a participant in the insulin signaling pathway and can interact with receptors similar to those recognized by insulin and insulin-like growth factors. Additionally INSL4 connects with IGF1 and IGF2 in these pathways highlighting its role in tissue development and metabolic regulation.
- Associated diseases and disorders
INSL4 links to conditions such as pregnancy-related trophoblastic disease and certain types of cancer. Its aberrant expression or function may lead to complications during pregnancy or contribute to the progression of malignant cells. In trophoblastic diseases INSL4 might interact with proteins like hCG while in cancer connections with oncogenes such as ERK or PI3K signaling components might occur. Understanding these associations can shed light on potential biomarker or therapeutic roles for INSL4 in clinical settings.
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1 product image
SDS-PAGE - Recombinant Human INSL4 protein (His tag) (ab276588)
SDS-PAGE analysis of ab276588
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