Recombinant Human INSL6 protein (His tag) is a Human Fragment protein, in the 1 to 198 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M P R L L R L S L L W L G L L L V R F S R E L S D I S S A R K L C G R Y L V K E I E K L C G H A N W S Q F R F E E E T P F S R L I A Q A S E K V E A Y S P Y Q F E S P Q T A S P A R G R G T N P V S T S W E E A V N S W E M Q S L P E Y K D K K G Y S P L G K T R E F S S S H N I N V Y I H E N A K F Q K K R R N K I K T L S N L F W G H H P Q R K R R G Y S E K C C L T G C T K E E L S I A C L P Y I D F
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May have a role in sperm development and fertilization.
Alternative names
RIF1, INSL6, Insulin-like peptide INSL6, Insulin-like peptide 6, Relaxin/insulin-like factor 1
Recommended products
Recombinant Human INSL6 protein (His tag) is a Human Fragment protein, in the 1 to 198 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9Y581-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M P R L L R L S L L W L G L L L V R F S R E L S D I S S A R K L C G R Y L V K E I E K L C G H A N W S Q F R F E E E T P F S R L I A Q A S E K V E A Y S P Y Q F E S P Q T A S P A R G R G T N P V S T S W E E A V N S W E M Q S L P E Y K D K K G Y S P L G K T R E F S S S H N I N V Y I H E N A K F Q K K R R N K I K T L S N L F W G H H P Q R K R R G Y S E K C C L T G C T K E E L S I A C L P Y I D F
- Accession
- Q9Y581
- Protein length
- Fragment
- Predicted molecular weight
- 22.1 kDa
- Amino acids
- 1 to 198
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
May have a role in sperm development and fertilization.
- Sequence similarities
Belongs to the insulin family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
INSL6 also known as Insulin-like peptide 6 is a protein involved in several physiological processes. It belongs to the insulin superfamily and has a molecular mass of approximately 12 kDa. Researchers find its expression mainly in the testis but it also appears in other tissues like the placenta. INSL6 plays a role in male reproductive physiology reflecting its expression and function.
- Biological function summary
The functions of INSL6 involve reproductive health and fertility. It does not currently appear to form part of a larger protein complex. Studies suggest its involvement in spermatogenesis the process of sperm cell development. INSL6 impacts the proliferation and differentiation of germ cells. These functions highlight its role in maintaining male fertility.
- Pathways
INSL6 interacts with processes connected to male reproductive health. It may influence the cyclic adenosine monophosphate (cAMP) signaling pathway which is important in numerous cellular responses. The protein INSL3 another member of the insulin superfamily associates with some similar pathways and shares functional parallels with INSL6 in reproductive biology. These pathways indicate its role in regulatory mechanisms influencing reproduction.
- Associated diseases and disorders
Research links INSL6 to male infertility. Mutations or abnormal expression levels may contribute to testicular dysfunction affecting spermatogenesis adversely. While studies continue another related protein relaxin may show therapeutic potential in similar reproductive disorders. The connection of INSL6 to these conditions emphasizes its importance in understanding and potentially treating male infertility.
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1 product image
SDS-PAGE - Recombinant Human INSL6 protein (His tag) (ab276664)
SDS-PAGE analysis of ab276664
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