Skip to main content

Recombinant Human Integrin alpha V + ITGB6 protein (Tagged) is a Human Fragment protein, in the 1 to 992 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.

Be the first to review this product! Submit a review

Images

SDS-PAGE - Recombinant Human Integrin alpha V + ITGB6 protein (Tagged) (AB277032), expandable thumbnail

Key facts

Purity
>95% SDS-PAGE
Endotoxin level
< 1 EU/µg
Expression system
HEK 293 cells
Tags
DDDDK tag C-Terminus His tag C-Terminus
Applications
SDS-PAGE
Biologically active
No

Sequence

This product is comprised of multiple sequences see

Amino acid sequence 1

M A F P P R R R L R L G P R G L P L L L S G L L L P L C R A F N L D V D S P A E Y S G P E G S Y F G F A V D F F V P S A S S R M F L L V G A P K A N T T Q P G I V E G G Q V L K C D W S S T R R C Q P I E F D A T G N R D Y A K D D P L E F K S H Q W F G A S V R S K Q D K I L A C A P L Y H W R T E M K Q E R E P V G T C F L Q D G T K T V E Y A P C R S Q D I D A D G Q G F C Q G G F S I D F T K A D R V L L G G P G S F Y W Q G Q L I S D Q V A E I V S K Y D P N V Y S I K Y N N Q L A T R T A Q A I F D D S Y L G Y S V A V G D F N G D G I D D F V S G V P R A A R T L G M V Y I Y D G K N M S S L Y N F T G E Q M A A Y F G F S V A A T D I N G D D Y A D V F I G A P L F M D R G S D G K L Q E V G Q V S V S L Q R A S G D F Q T T K L N G F E V F A R F G S A I A P L G D L D Q D G F N D I A I A A P Y G G E D K K G I V Y I F N G R S T G L N A V P S Q I L E G Q W A A R S M P P S F G Y S M K G A T D I D K N G Y P D L I V G A F G V D R A I L Y R A R P V I T V N A G L E V Y P S I L N Q D N K T C S L P G T A L K V S C F N V R F C L K A D G K G V L P R K L N F Q V E L L L D K L K Q K G A I R R A L F L Y S R S P S H S K N M T I S R G G L M Q C E E L I A Y L R D E S E F R D K L T P I T I F M E Y R L D Y R T A A D T T G L Q P I L N Q F T P A N I S R Q A H I L L D C G E D N V C K P K L E V S V D S D Q K K I Y I G D D N P L T L I V K A Q N Q G E G A Y E A E L I V S I P L Q A D F I G V V R N N E A L A R L S C A F K T E N Q T R Q V V C D L G N P M K A G T Q L L A G L R F S V H Q Q S E M D T S V K F D L Q I Q S S N L F D K V S P V V S H K V D L A V L A A V E I R G V S S P D H V F L P I P N W E H K E N P E T E E D V G P V V Q H I Y E L R N N G P S S F S K A M L H L Q W P Y K Y N N N T L L Y I L H Y D I D G P M N C T S D M E I N P L R I K I S S L Q T T E K N D T V A G Q G E R D H L I T K R D L A L S E G D I H T L G C G V A Q C L K I V C Q V G R L D R G K S A I L Y V K S L L W T E T F M N K E N Q N H S Y S L K S S A S F N V I E F P Y K N L P I E D I T N S T L V T T N V T W G I Q P A P M P V

Reactivity data

Application
SDS-PAGE
Reactivity
Reacts
Dilution info
-
Notes

-

Target data

Function

The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 acts as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428). (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Additional Targets

Integrin beta-6

Alternative names

Recommended products

Recombinant Human Integrin alpha V + ITGB6 protein (Tagged) is a Human Fragment protein, in the 1 to 992 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.

Key facts

Purity
>95% SDS-PAGE
Endotoxin level
< 1 EU/µg
Expression system
HEK 293 cells
Applications
SDS-PAGE
Accession
P06756-1
Animal free
No
Species
Human
Concentration
Loading...
Storage buffer

pH: 7.4
Constituents: 100% PBS

Sequence info

Amino acid sequence 1

M A F P P R R R L R L G P R G L P L L L S G L L L P L C R A F N L D V D S P A E Y S G P E G S Y F G F A V D F F V P S A S S R M F L L V G A P K A N T T Q P G I V E G G Q V L K C D W S S T R R C Q P I E F D A T G N R D Y A K D D P L E F K S H Q W F G A S V R S K Q D K I L A C A P L Y H W R T E M K Q E R E P V G T C F L Q D G T K T V E Y A P C R S Q D I D A D G Q G F C Q G G F S I D F T K A D R V L L G G P G S F Y W Q G Q L I S D Q V A E I V S K Y D P N V Y S I K Y N N Q L A T R T A Q A I F D D S Y L G Y S V A V G D F N G D G I D D F V S G V P R A A R T L G M V Y I Y D G K N M S S L Y N F T G E Q M A A Y F G F S V A A T D I N G D D Y A D V F I G A P L F M D R G S D G K L Q E V G Q V S V S L Q R A S G D F Q T T K L N G F E V F A R F G S A I A P L G D L D Q D G F N D I A I A A P Y G G E D K K G I V Y I F N G R S T G L N A V P S Q I L E G Q W A A R S M P P S F G Y S M K G A T D I D K N G Y P D L I V G A F G V D R A I L Y R A R P V I T V N A G L E V Y P S I L N Q D N K T C S L P G T A L K V S C F N V R F C L K A D G K G V L P R K L N F Q V E L L L D K L K Q K G A I R R A L F L Y S R S P S H S K N M T I S R G G L M Q C E E L I A Y L R D E S E F R D K L T P I T I F M E Y R L D Y R T A A D T T G L Q P I L N Q F T P A N I S R Q A H I L L D C G E D N V C K P K L E V S V D S D Q K K I Y I G D D N P L T L I V K A Q N Q G E G A Y E A E L I V S I P L Q A D F I G V V R N N E A L A R L S C A F K T E N Q T R Q V V C D L G N P M K A G T Q L L A G L R F S V H Q Q S E M D T S V K F D L Q I Q S S N L F D K V S P V V S H K V D L A V L A A V E I R G V S S P D H V F L P I P N W E H K E N P E T E E D V G P V V Q H I Y E L R N N G P S S F S K A M L H L Q W P Y K Y N N N T L L Y I L H Y D I D G P M N C T S D M E I N P L R I K I S S L Q T T E K N D T V A G Q G E R D H L I T K R D L A L S E G D I H T L G C G V A Q C L K I V C Q V G R L D R G K S A I L Y V K S L L W T E T F M N K E N Q N H S Y S L K S S A S F N V I E F P Y K N L P I E D I T N S T L V T T N V T W G I Q P A P M P V
Accession
P18564
Protein length
Fragment
Predicted molecular weight
111.1 kDa
Amino acids
1 to 992
Nature
Recombinant
Tags
DDDDK tag C-Terminus

Amino acid sequence 2

M G I E L L C L F F L F L G R N D H V Q G G C A L G G A E T C E D C L L I G P Q C A W C A Q E N F T H P S G V G E R C D T P A N L L A K G C Q L N F I E N P V S Q V E I L K N K P L S V G R Q K N S S D I V Q I A P Q S L I L K L R P G G A Q T L Q V H V R Q T E D Y P V D L Y Y L M D L S A S M D D D L N T I K E L G S R L S K E M S K L T S N F R L G F G S F V E K P V S P F V K T T P E E I A N P C S S I P Y F C L P T F G F K H I L P L T N D A E R F N E I V K N Q K I S A N I D T P E G G F D A I M Q A A V C K E K I G W R N D S L H L L V F V S D A D S H F G M D S K L A G I V I P N D G L C H L D S K N E Y S M S T V L E Y P T I G Q L I D K L V Q N N V L L I F A V T Q E Q V H L Y E N Y A K L I P G A T V G L L Q K D S G N I L Q L I I S A Y E E L R S E V E L E V L G D T E G L N L S F T A I C N N G T L F Q H Q K K C S H M K V G D T A S F S V T V N I P H C E R R S R H I I I K P V G L G D A L E L L V S P E C N C D C Q K E V E V N S S K C H H G N G S F Q C G V C A C H P G H M G P R C E C G E D M L S T D S C K E A P D H P S C S G R G D C Y C G Q C I C H L S P Y G N I Y G P Y C Q C D N F S C V R H K G L L C G G N G D C D C G E C V C R S G W T G E Y C N C T T S T D S C V S E D G V L C S G R G D C V C G K C V C T N P G A S G P T C E R C P T C G D P C N S K R S C I E C H L S A A G Q A R E E C V D K C K L A G A T I S E E E D F S K D G S V S C S L Q G E N E C L I T F L I T T D N E G K T I I H S I N E K D C P K P P N
Accession
P18564
Protein length
Fragment
Predicted molecular weight
79.3 kDa
Amino acids
1 to 707
Nature
Recombinant
Tags
His tag C-Terminus

Specifications

Form
Lyophilized

General info

Function

The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 acts as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428).

Sequence similarities

Belongs to the integrin alpha chain family.

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

Integrin alpha V ITGB6 also known as alpha V beta 6 is a heterodimeric integrin protein involved in cell adhesion and signaling. This integrin weighs approximately 135 kDa and is commonly expressed in epithelial cells. Its mechanical function involves mediating cell attachment to the extracellular matrix by binding to specific ligands such as fibronectin vitronectin and latent TGF-beta. It plays an important role in maintaining tissue architecture and facilitating cellular communication with their environment.

Biological function summary

Integrin alpha V beta 6 is part of a larger integrin family known to regulate various cellular processes including proliferation differentiation and migration. It forms a complex with other proteins to activate signaling pathways that control immune response and wound healing. Through binding with latent TGF-beta it contributes to activating this important cytokine modulating immune functions and promoting epithelial to mesenchymal transition in wound repair.

Pathways

Integrin alpha V beta 6 interacts within key signaling pathways like the TGF-beta signaling pathway and the MAPK/ERK pathway. It modulates signals through related proteins such as TGF-beta receptors which are critical in controlling cellular responses to external cues. This integrin enhances pathway interactions that can lead to changes in gene expression influencing cell fate decisions during development and wound healing.

Associated diseases and disorders

Integrin alpha V beta 6 has been linked to fibrosis and cancer progression. In fibrotic diseases like idiopathic pulmonary fibrosis the protein facilitates activation of TGF-beta leading to tissue scarring and dysfunction. In cancer particularly in oral carcinoma integrin alpha V beta 6 interacts with matrix metalloproteinases contributing to tumor invasion and metastasis. These connections underline its potential as therapeutic target in the treatment of fibrotic conditions and certain types of cancer.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • SDS-PAGE - Recombinant Human Integrin alpha V + ITGB6 protein (Tagged) (ab277032), expandable thumbnail

    SDS-PAGE - Recombinant Human Integrin alpha V + ITGB6 protein (Tagged) (ab277032)

    SDS-PAGE analysis of ab277032

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com