Recombinant Human Interferon alpha 8 protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Interferon alpha 8 also known as IFN-α8 is a protein involved in the immune response. It belongs to the type I interferon family and plays an important role in antiviral defense. The protein has an approximate molecular mass of 20 to 25 kDa and is encoded by the IFNA8 gene. Expression of IFN-α8 is common in immune cells such as leukocytes and is often upregulated during viral infections. It works mechanically by binding to the type I interferon receptor leading to the activation of signaling cascades that help fight viral pathogens.

Biological function summary

The functions of interferon alpha 8 include modulating the immune system and enhancing the antiviral state within cells. This protein is not part of a known complex but interacts with multiple parts of the immune system. It promotes the expression of various interferon-stimulated genes that contribute to antiviral activity. These actions not only inhibit viral replication but also stimulate natural killer cells and increase antigen presentation making it an important mediator in the body's defense mechanisms.

Pathways

Interferon alpha 8 contributes to the JAK-STAT signaling pathway which regulates immune response and cell growth. It is related to proteins such as STAT1 and STAT2 in this pathway which are known for transmitting signals from the cell membrane to the nucleus influencing gene expression. Additionally IFN-α8 is part of the interferon regulatory factor (IRF) pathway which helps modulate the transcription of interferon-induced genes. This involvement reinforces its role in controlling immune cell activities and antiviral defense.

Interferon alpha 8 influences conditions like hepatitis C and autoimmune diseases including systemic lupus erythematosus. Its contribution to these diseases often ties to its role in inappropriate immune activation or persistent viral infection. For instance in hepatitis C elevated levels of IFN-α8 can occur which correlates with the immune system's attempt to limit viral spread. Similarly in autoimmune disorders its misregulation might contribute to chronic inflammation. Proteins like IRF7 and IFN-α1 are also involved in such conditions linking them to the complex interactions mediated by interferon alpha 8.