Recombinant Human Interferon alpha10 protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Interferon alpha10 also known as IFN-α10 is a protein belonging to the type I interferon family. It has a molecular mass of approximately 20 kDa. This protein is known for its role in immune response and is expressed in various cell types including lymphocytes and dendritic cells. IFN-α10 functions as a cytokine meaning it is important for communication between cells to initiate and regulate the defense against pathogens.

Biological function summary

IFN-α10 plays an important role in antiviral defense immune surveillance and modulation of the immune response. This cytokine can interfere with viral replication processes within host cells assisting the body's natural defenses in controlling viral infections. IFN-α10 is part of the cytokine signaling complex engaging with cell surface receptors to initiate the JAK-STAT signaling pathway. This induces the expression of genes responsible for antiviral activities and immune modulation.

Pathways

IFN-α10 engages in the JAK-STAT pathway and this influences cell survival cell proliferation and apoptosis. It interacts with other proteins like STAT1 and STAT2 which are critical for transmitting signals from cytokine receptors to the cell nucleus. IFN-α10 is also involved in the antiviral pathway working in conjunction with other interferons such as IFN-β to enhance the immune system's ability to combat viral infections.

IFN-α10 has links to conditions such as viral hepatitis and systemic lupus erythematosus (SLE). In the context of viral hepatitis IFN-α10's anti-viral actions help to control viral replication within the liver. In SLE there is often an upregulation of type I interferons including IFN-α10 which can contribute to disease pathogenesis by affecting immune regulation. IFN-α10 connects to other interferons such as IFN-α2 within these diseases both of which play roles in moderating immune responses and influencing disease progression.