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AB164779

Recombinant Human Invadolysin protein (GST tag N-Terminus)

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Recombinant Human Invadolysin protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 655 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Leishmanolysin-like peptidase, Invadolysin, LMLN

1 Images
SDS-PAGE - Recombinant Human Invadolysin protein (GST tag N-Terminus) (AB164779)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Invadolysin protein (GST tag N-Terminus) (AB164779)

ab164779 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q96KR4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MVTTLGPKMAAEWGGGVGYSGSGPGRSRWRWSGSVWVRSVLLLLGGLRASATSTPVSLGSSPPCRHHVPSDTEVINKVHLKANHVVKRDVDEHLRIKTVYDKSVEELLPEKKNLVKNKLFPQAISYLEKTFQVRRPAGTILLSRQCATNQYLRKENDPHRYCTGECAAHTKCGPVIVPEEHLQQCRVYRGGKWPHGAVGVPDQEGISDADFVLYVGALATERCSHENIISYAAYCQQEANMDRPIAGYANLCPNMISTQPQEFVGMLSTVKHEVIHALGFSAGLFAFYHDKDGNPLTSRFADGLPPFNYSLGLYQWSDKVVRKVERLWDVRDNKIVRHTVYLLVTPRVVEEARKHFDCPVLEGMELENQGGVGTELNHWEKRLLENEAMTGSHTQNRVLSRITLALMEDTGRQMLSPYCDTLRSNPLQLTCRQDQRAVAVCNLQKFPKPLPQEYQYFDELSGIPAEDLPYYGGSVEIADYCPFSQEFSWHLSGEYQRSSDCRILENQPEIFKNYGAEKYGPHSVCLIQKSAFVMEKCERKLSYPDWGSGCYQVSCSPQGLKVWVQDTSYLCSRAGQVLPVSIQMNGWIHDGNLLCPSCWDFCELCPPETDPPATNLTRALPLDLCSCSSSLVVTLWLLLGNLFPLLAGFLLCIWH","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":655,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q96KR4","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Invadolysin also known as KIAA0174 or NET39 is a serine protease involved in cell migration and invasion. This enzyme has a mass of approximately 90 kDa. Invadolysin expresses in various tissues including those of the nervous system where it plays a role in development. In several cancer cells higher expression levels suggest a role in tumor progression. Its presence in cellular membrane structures indicates its importance in cellular interactions and movement.
Biological function summary

Invadolysin facilitates cell motility by remodeling the extracellular matrix and promoting cytoskeletal changes. It acts within protease complexes that regulate cellular processes like division and differentiation. In the nervous system invadolysin aids in neurodevelopment by guiding neural cells to their proper destinations. Its role in angiogenesis the formation of new blood vessels highlights its significance in tissue growth and repair processes.

Pathways

Research shows invadolysin's involvement in the MAPK signaling and Wnt pathways both important for cell growth and division. Within these pathways invadolysin interacts with proteins such as ERK and β-catenin influencing cellular adhesion and proliferation. Its activity within these pathways highlights its role in transmitting signals that direct cell behavior and fate.

Studies link invadolysin to cancer and neurodegenerative disorders. Its upregulation in cancers like melanoma and breast cancer suggests its role in promoting metastasis. In Alzheimer's disease dysregulated invadolysin activity may disrupt cellular processes contributing to neuronal death. Connections with proteins like tau in neurodegenerative disorders highlight the enzyme's potential impact on diseases characterized by protein aggregation and cellular dysfunction.
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Specifications

Form

Liquid

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General info

Function

Metalloprotease.

Sequence similarities

Belongs to the peptidase M8 family.

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Product protocols

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Target data

Metalloprotease.
See full target information LMLN
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