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AB224848

Recombinant Human IP6K1 protein (His tag)

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Recombinant Human IP6K1 protein (His tag) is a Human Full Length protein, in the 1 to 441 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

IHPK1, KIAA0263, IP6K1, Inositol hexakisphosphate kinase 1, InsP6 kinase 1, Inositol hexaphosphate kinase 1

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q92551

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHSEVPFQMLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ","proteinLength":"Full Length","predictedMolecularWeight":"66.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":441,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q92551","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein inositol hexakisphosphate kinase 1 (IP6K1) also known as IHPK1 plays an important mechanical role in cellular signaling. It catalyzes the conversion of inositol hexakisphosphate (IP6) to diphosphoinositol pentakisphosphate (IP7). IP6K1 has a molecular mass of approximately 48 kDa. It is expressed in various tissues including the brain testis and pancreas where it is involved in multiple cellular processes.
Biological function summary

IP6K1 influences several critical cell functions such as energy metabolism cell migration and apoptosis. It also participates in the regulation of insulin secretion. IP6K1 does not primarily form part of a complex; however it interacts with proteins that impact these biological functions. Its role in metabolism and signaling pathways marks it as a significant contributor to maintaining cellular homeostasis.

Pathways

IP6K1 plays a part in the inositol phosphate metabolism and insulin signaling pathways. Within these pathways IP6K1 interacts closely with proteins such as Akt mTOR and other kinases modulating their activities. These interactions affect cellular energy status and influence growth factor signaling pathways impacting numerous downstream biological processes.

IP6K1's activity links it to conditions such as type 2 diabetes and obesity. In type 2 diabetes IP6K1 interacts with insulin-signaling proteins affecting glucose homeostasis and insulin sensitivity. The protein's role in obesity relates to its influence on energy metabolism as it can impact energy expenditure and fat storage with potential interactions involving with proteins like leptin and AMPK.
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Specifications

Form

Liquid

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General info

Function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Sequence similarities

Belongs to the inositol phosphokinase (IPK) family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
See full target information IP6K1
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