Recombinant human IPL-1/STK13/Aurora C protein
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Recombinant human IPL-1/STK13/Aurora C protein is a Human Full Length protein, expressed in Baculovirus infected Sf9 cells, with >80%, suitable for SDS-PAGE, FuncS.
View Alternative Names
AIE2, AIK3, AIRK3, ARK3, STK13, AURKC, Aurora kinase C, Aurora 3, Aurora/IPL1-related kinase 3, Aurora/IPL1/Eg2 protein 2, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase aurora-C, ARK-3, Aurora-related kinase 3
- FuncS
Unknown
Functional Studies - Recombinant human IPL-1/STK13/Aurora C protein (AB63177)
The specific activity of IPL-1/STK13/Aurora C (ab63177) was determined to be 65 nmol/min/mg as per activity assay protocol
- FuncS
Unknown
Functional Studies - Recombinant human IPL-1/STK13/Aurora C protein (AB63177)
Kinase activity plot
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human IPL-1/STK13/Aurora C protein (AB63177)
SDS PAGE analysis of ab63177
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human IPL-1/STK13/Aurora C protein (AB63177)
ab63177 on SDS-PAGE, MW ~61 kDa
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
IPL-1 functions in chromosomal alignment and cytokinesis during cell division. It forms part of the chromosomal passenger complex (CPC) along with INCENP Survivin and Borealin. This complex is essential for correcting errors in chromosome segregation. IPL-1's activity helps maintain genomic stability by ensuring that cells divide correctly. Given its role in the chromosomal passenger complex IPL-1 is critical in monitoring and controlling the accurate distribution of genetic material between daughter cells.
Pathways
IPL-1 is intricately involved in cellular processes like the mitotic spindle checkpoint and the regulation of the mitotic cell cycle. It interacts with other proteins such as Aurora B which shares similar functions in the mitotic pathway. IPL-1 helps coordinate the activities of these pathways and proteins to ensure orderly cell division. Through these pathways IPL-1 influences the balance of cell proliferation and cell death which is important for normal organismal development and function.
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Sequence similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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