Recombinant Human IQGAP3 protein

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The target IQGAP3 also known as IQ motif containing GTPase activating protein 3 is a protein with a mass of approximately 189 kDa. Mechanically IQGAP3 functions as a scaffolding protein and interacts with cytoskeletal elements and signaling molecules. It plays important roles in the regulation of cell morphology and motility. Practically this protein is expressed in various tissues including brain lung and liver with notable roles in the nervous and respiratory systems.

Biological function summary

IQGAP3 contributes to the regulation of cell adhesion migration and proliferation. This protein operates as part of a multi-protein complex where it interacts with actin filaments and signaling molecules like Cdc42 and Rac1. These interactions facilitate the remodeling of the cytoskeleton thereby influencing cellular dynamics and functions necessary for tissue development and repair.

Pathways

IQGAP3 is involved in the MAPK/ERK signaling and PI3K/AKT pathways. This protein cooperates closely with MAPK1 (ERK2) and AKT1 both of which are important for transducing signals related to cell survival and proliferation. IQGAP3’s interactions with these pathways suggest its role in regulating processes such as cell cycle progression and response to extrinsic signals.

Associated diseases and disorders

Researchers have linked IQGAP3 to cancer and neurological disorders. IQGAP3 affects tumorigenesis especially in colorectal cancer partly due to its interaction with beta-catenin. Furthermore its expression and activity correlate with neural development alterations hinting at a connection to neurodevelopmental disorders. Given its interactions with proteins like APC and Rac1 studying IQGAP3 can offer insights into its roles in disease pathogenesis and potential therapeutic targeting.