Recombinant Human ISOC2 protein (denatured) is a Human Full Length protein, in the 59 to 205 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S E Q Y P Q G L G P T V P E L G T E G L R P L A K T C F S M V P A L Q Q E L D S R P Q L R S V L L C G I E A Q A C I L N T T L D L L D R G L Q V H V V V D A C S S R S Q V D R L V A L A R M R Q S G A F L S T S E G L I L Q L V G D A V H P Q F K E I Q K L I K E P A P D S G L L G L F Q G Q N S L L H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
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Target data
Alternative names
Isochorismatase domain-containing protein 2, ISOC2
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Recombinant Human ISOC2 protein (denatured) is a Human Full Length protein, in the 59 to 205 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q96AB3-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S E Q Y P Q G L G P T V P E L G T E G L R P L A K T C F S M V P A L Q Q E L D S R P Q L R S V L L C G I E A Q A C I L N T T L D L L D R G L Q V H V V V D A C S S R S Q V D R L V A L A R M R Q S G A F L S T S E G L I L Q L V G D A V H P Q F K E I Q K L I K E P A P D S G L L G L F Q G Q N S L L H
- Accession
- Q96AB3
- Protein length
- Full Length
- Predicted molecular weight
- 18 kDa
- Amino acids
- 59 to 205
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab171594 was purified using conventional chromatography.
General info
- Sequence similarities
Belongs to the isochorismatase family.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The ISOC2 protein also known as Isochorismatase Domain Containing 2 is an enzyme with a molecular mass of approximately 30 kDa. This protein localizes in the cytoplasm and is expressed in several tissues including the liver and kidney. ISOC2 functions as an isochorismatase involved in catalyzing hydrolysis reactions which play roles in diverse cellular processes. The enzyme's distinct domain structure allows it to participate effectively in its mechanical roles within the cell.
- Biological function summary
The function of ISOC2 extends to participating in cellular metabolic processes. It often functions within protein complexes that modulate specific biochemical pathways. ISOC2's enzymatic activity links with pathways regulating metabolite flux and cellular homeostasis which is essential for maintaining cellular equilibrium. The enzyme's contribution to these pathways emphasizes its role in stabilizing intracellular environments.
- Pathways
ISOC2 interacts with metabolic pathways particularly those involving core physiological metabolites. It shows connections to regulatory pathways such as the cholesterol biosynthesis pathway. In these pathways ISOC2 may interact with other related proteins like HMGCR which plays a major role in cholesterol synthesis. The involvement of ISOC2 in these pathways highlights its importance in maintaining metabolic stability.
- Associated diseases and disorders
ISOC2 links to metabolic syndromes and conditions like hypocholesterolemia and liver dysfunction. These conditions often involve disruptions in metabolic pathways where ISOC2 exerts significant regulatory effects. Additionally ISOC2's activity can connect to HMGCR as disruptions in cholesterol homeostasis can lead to metabolic-related diseases. Understanding the role of ISOC2 in these disorders aids in identifying potential therapeutic targets.
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1 product image
SDS-PAGE - Recombinant Human ISOC2 protein (denatured) (ab171594)
15% SDS-PAGE analysis of ab171594 at 3µg.
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