Recombinant Human ITIH1/SHAP protein is a Human Full Length protein, in the 1 to 911 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M D G A M G P R G L L L C M Y L V S L L I L Q A M P A L G S A T G R S K S S E K R Q A V D T A V D G V F I R S L K V N C K V T S R F A H Y V V T S Q V V N T A N E A R E V A F D L E I P K T A F I S D F A V T A D G N A F I G D I K D K V T A W K Q Y R K A A I S G E N A G L V R A S G R T M E Q F T I H L T V N P Q S K V T F Q L T Y E E V L K R N H M Q Y E I V I K V K P K Q L V H H F E I D V D I F E P Q G I S K L D A Q A S F L P K E L A A Q T I K K S F S G K K G H V L F R P T V S Q Q Q S C P T C S T S L L N G H F K V T Y D V S R D K I C D L L V A N N H F A H F F A P Q N L T N M N K N V V F V I D I S G S M R G Q K V K Q T K E A L L K I L G D M Q P G D Y F D L V L F G T R V Q S W K G S L V Q A S E A N L Q A A Q D F V R G F S L D E A T N L N G G L L R G I E I L N Q V Q E S L P E L S N H A S I L I M L T D G D P T E G V T D R S Q I L K N V R N A I R G R F P L Y N L G F G H N V D F N F L E V M S M E N N G R A Q R I Y E D H D A T Q Q L Q G F Y S Q V A K P L L V D V D L Q Y P Q D A V L A L T Q N H H K Q Y Y E G S E I V V A G R I A D N K Q S S F K A D V Q A H G E G Q E F S I T C L V D E E E M K K L L R E R G H M L E N H V E R L W A Y L T I Q E L L A K R M K V D R E V R A N L S S Q A L R M S L D Y G F V T P L T S M S I R G M A D Q D G L K P T I D K P S E D S P P L E M L G P R R T F V L S A L Q P S P T H S S S N T Q R L P D R V T G V D T D P H F I I H V P Q K E D T L C F N I N E E P G V I L S L V Q D P N T G F S V N G Q L I G N K A R S P G Q H D G T Y F G R L G I A N P A T D F Q L E V T P Q N I T L N P G F G G P V F S W R D Q A V L R Q D G V V V T I N K K R N L V V S V D D G G T F E V V L H R V W K G S S V H Q D F L G F Y V L D S H R M S A R T H G L L G Q F F H P I G F E V S D I H P G S D P T K P D A T M V V R N R R L T V T R G L Q K D Y S K D P W H G A E V S C W F I H N N G A G L I D G A Y T D Y I V P D I F
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes Recombinant protein |
Target data
Function
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.
Alternative names
IGHEP1, ITIH1, Inter-alpha-trypsin inhibitor heavy chain H1, ITI heavy chain H1, ITI-HC1, Inter-alpha-inhibitor heavy chain 1, Inter-alpha-trypsin inhibitor complex component III, Serum-derived hyaluronan-associated protein, SHAP
Recommended products
Recombinant Human ITIH1/SHAP protein is a Human Full Length protein, in the 1 to 911 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P19827-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.3% Glutathione
Sequence info
Amino acid sequence
- M D G A M G P R G L L L C M Y L V S L L I L Q A M P A L G S A T G R S K S S E K R Q A V D T A V D G V F I R S L K V N C K V T S R F A H Y V V T S Q V V N T A N E A R E V A F D L E I P K T A F I S D F A V T A D G N A F I G D I K D K V T A W K Q Y R K A A I S G E N A G L V R A S G R T M E Q F T I H L T V N P Q S K V T F Q L T Y E E V L K R N H M Q Y E I V I K V K P K Q L V H H F E I D V D I F E P Q G I S K L D A Q A S F L P K E L A A Q T I K K S F S G K K G H V L F R P T V S Q Q Q S C P T C S T S L L N G H F K V T Y D V S R D K I C D L L V A N N H F A H F F A P Q N L T N M N K N V V F V I D I S G S M R G Q K V K Q T K E A L L K I L G D M Q P G D Y F D L V L F G T R V Q S W K G S L V Q A S E A N L Q A A Q D F V R G F S L D E A T N L N G G L L R G I E I L N Q V Q E S L P E L S N H A S I L I M L T D G D P T E G V T D R S Q I L K N V R N A I R G R F P L Y N L G F G H N V D F N F L E V M S M E N N G R A Q R I Y E D H D A T Q Q L Q G F Y S Q V A K P L L V D V D L Q Y P Q D A V L A L T Q N H H K Q Y Y E G S E I V V A G R I A D N K Q S S F K A D V Q A H G E G Q E F S I T C L V D E E E M K K L L R E R G H M L E N H V E R L W A Y L T I Q E L L A K R M K V D R E V R A N L S S Q A L R M S L D Y G F V T P L T S M S I R G M A D Q D G L K P T I D K P S E D S P P L E M L G P R R T F V L S A L Q P S P T H S S S N T Q R L P D R V T G V D T D P H F I I H V P Q K E D T L C F N I N E E P G V I L S L V Q D P N T G F S V N G Q L I G N K A R S P G Q H D G T Y F G R L G I A N P A T D F Q L E V T P Q N I T L N P G F G G P V F S W R D Q A V L R Q D G V V V T I N K K R N L V V S V D D G G T F E V V L H R V W K G S S V H Q D F L G F Y V L D S H R M S A R T H G L L G Q F F H P I G F E V S D I H P G S D P T K P D A T M V V R N R R L T V T R G L Q K D Y S K D P W H G A E V S C W F I H N N G A G L I D G A Y T D Y I V P D I F
- Accession
- P19827
- Protein length
- Full Length
- Predicted molecular weight
- 126.28 kDa
- Amino acids
- 1 to 911
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
- Sequence similarities
Belongs to the ITIH family.
- Post-translational modifications
Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as ITIH1.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The target ITIH1 also known as Inter-alpha-trypsin inhibitor heavy chain H1 is a component of the inter-alpha-inhibitor family. ITIH1 has an approximate mass of 100 kDa. This protein is mainly expressed in the liver and secreted into the blood participating in the extracellular matrix. ITIH1 works by stabilizing urinary trypsin inhibitors and playing a role in maintaining structural integrity in tissues especially during inflammation and tissue repair.
- Biological function summary
ITIH1 interacts with other macromolecules to form complexes that modulate the extracellular environment. It is part of a complex that involves proteins like bikunin which is important in the formation of the inter-alpha-inhibitor complex. This complex plays important roles in modulating inflammation and is implicated in various physiological processes like immunological responses.
- Pathways
ITIH1 is integrated into the acute-phase response pathway which responds to inflammation. It cooperates with proteins such as ITIH2 another member of the inter-alpha-trypsin inhibitor family to mediate immune and inflammatory processes. Furthermore ITIH1 participates in the protective mechanisms against pathogenic invasion through the complement pathway.
- Associated diseases and disorders
ITIH1 has associations with conditions such as sepsis and liver cirrhosis. In sepsis ITIH1 levels may be altered influencing the inflammatory response and affecting patient outcomes. The interaction between ITIH1 and proteins involved in these diseases such as tumor necrosis factor-alpha (TNF-alpha) suggests its role as a potential biomarker or therapeutic target in these pathologies.
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1 product image
SDS-PAGE - Recombinant Human ITIH1/SHAP protein (ab114721)
12.5% SDS-PAGE Stained with Coomassie Blue
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