Recombinant Human ITIH5 protein (Tagged)

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ITIH5 also known as Inter-alpha-trypsin inhibitor heavy chain 5 belongs to the inter-alpha-trypsin inhibitor family. With a molecular mass of around 99 kDa ITIH5 expresses mainly in the extracellular matrix of tissues such as skin colon testis and placenta. Researchers also observe its presence in certain cancerous tissues indicating its potential involvement in tumor processes.

Biological function summary

ITIH5 plays a role in extracellular matrix stabilization and tissue homeostasis. This protein participates in forming a protein complex with other inter-alpha-trypsin inhibitors which contributes to its functional capacity. ITIH5 shows importance in processes like cellular senescence and maintaining tissue integrity making it a relevant target in the context of cellular and systemic homeostasis.

Pathways

Several biological processes incorporate ITIH5 particularly those related to matrix remodeling and inflammation. One significant pathway involves the hyaluronan biosynthesis where ITIH5 interacts with proteins like TSG-6 facilitating the matrix assembly and stability. Another relevant interaction includes its association with matrix metalloproteinases mediating tissue remodeling during wound healing and inflammatory responses.

Associated diseases and disorders

ITIH5 associates notably with cancer where its expression levels vary in relation to tumor progression. Studies suggest a connection between ITIH5 and breast cancer with altered expression linked to metastasis and proliferation. Additionally the protein shows potential involvement in fibrosis where its interaction with TSG-6 and matrix metalloproteinases might influence fibrotic tissue formation and resolution.