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AB238235

Recombinant Human ITIH5 protein (Tagged)

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Recombinant Human ITIH5 protein (Tagged) is a Human Fragment protein, in the 35 to 161 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

KIAA1953, PP14776, UNQ311/PRO354, ITIH5, Inter-alpha-trypsin inhibitor heavy chain H5, ITI heavy chain H5, ITI-HC5, Inter-alpha-inhibitor heavy chain 5

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SDS-PAGE - Recombinant Human ITIH5 protein (Tagged) (AB238235)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ITIH5 protein (Tagged) (AB238235)

(Tris-Glycine gel) Discontinuous DSD-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab238235.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

6x His tag N-Terminus SUMO tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q86UX2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"VPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFITNFTMLIGDKVYQGEITEREKKSGDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEE","proteinLength":"Fragment","predictedMolecularWeight":"30.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":161,"aminoAcidStart":35,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q86UX2","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ITIH5 also known as Inter-alpha-trypsin inhibitor heavy chain 5 belongs to the inter-alpha-trypsin inhibitor family. With a molecular mass of around 99 kDa ITIH5 expresses mainly in the extracellular matrix of tissues such as skin colon testis and placenta. Researchers also observe its presence in certain cancerous tissues indicating its potential involvement in tumor processes.
Biological function summary

ITIH5 plays a role in extracellular matrix stabilization and tissue homeostasis. This protein participates in forming a protein complex with other inter-alpha-trypsin inhibitors which contributes to its functional capacity. ITIH5 shows importance in processes like cellular senescence and maintaining tissue integrity making it a relevant target in the context of cellular and systemic homeostasis.

Pathways

Several biological processes incorporate ITIH5 particularly those related to matrix remodeling and inflammation. One significant pathway involves the hyaluronan biosynthesis where ITIH5 interacts with proteins like TSG-6 facilitating the matrix assembly and stability. Another relevant interaction includes its association with matrix metalloproteinases mediating tissue remodeling during wound healing and inflammatory responses.

ITIH5 associates notably with cancer where its expression levels vary in relation to tumor progression. Studies suggest a connection between ITIH5 and breast cancer with altered expression linked to metastasis and proliferation. Additionally the protein shows potential involvement in fibrosis where its interaction with TSG-6 and matrix metalloproteinases might influence fibrotic tissue formation and resolution.
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Specifications

Form

Liquid

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General info

Function

May act as a tumor suppressor.

Sequence similarities

Belongs to the ITIH family.

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Product protocols

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Target data

May act as a tumor suppressor.
See full target information ITIH5
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Product promise

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