Recombinant Human ITPKB protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The biological target Inositol-trisphosphate 3-kinase B (ITPKB) plays an important role mechanically in cellular signaling by phosphorylating inositol 145-trisphosphate (IP3) to produce inositol 1345-tetrakisphosphate (IP4). Also known as ITPK-B or IP3 3-kinase B it is a 66-kDa protein expressed mainly in the brain hematopoietic cells and the immune system. This enzyme's activity regulates intracellular calcium levels thereby influencing various cellular processes.

Biological function summary

ITPKB modulates immune system processes and neural function. It does not form part of a larger protein complex but interacts with other molecules to influence cellular activities. Regulation of calcium signaling through the activity of ITPKB affects T-cell development and function as well as neurogenesis in the brain. By altering IP3 and IP4 levels ITPKB has an impact on the pathways that modulate cell proliferation and differentiation.

Pathways

ITPKB is integral to calcium signaling and the phosphoinositide pathway. In the calcium signaling pathway it controls the production of IP4 which in turn regulates calcium homeostasis and related downstream effects. In the phosphoinositide pathway ITPKB works together with related proteins like IP3 receptors and phospholipase C to affect signal transduction. These pathways are important for immune response and neural development.

ITPKB is linked to immune deficiency and neurological conditions. Dysregulation of this protein can lead to autoimmune diseases due to its role in T-cell regulation. Connections also exist between ITPKB and proteins like calcineurin where imbalance can contribute to neurological disorders such as schizophrenia. Restoration of ITPKB function offers potential therapeutic approaches for managing these diseases.