Recombinant Human IVD protein (His tag N-Terminus)
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Recombinant Human IVD protein (His tag N-Terminus) is a Human Full Length protein, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
View Alternative Names
IVD, Butyryl-CoA dehydrogenase
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human IVD protein (AB93747)
15% SDS-PAGE showing ab93747 (3ug)
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Isovaleryl-CoA dehydrogenase acts as an important enzyme in branched-chain amino acid metabolism. It is part of a complex enzyme system involved in leucine degradation. As such it contributes to maintaining energy homeostasis by converting leucine into acetoacetate and acetyl-CoA important components of energy production and lipid synthesis. IVD's functional activity supports metabolic processes and regulates amino acid levels in cells.
Pathways
Isovaleryl-CoA dehydrogenase participates in the leucine degradation pathway and the wider branched-chain amino acid degradation pathway. This pathway integrates with other metabolic pathways such as the tricarboxylic acid (TCA) cycle and the ketone body synthesis pathway. Related proteins in this context include enzymes such as 3-methylcrotonyl-CoA carboxylase and HMG-CoA reductase which also play roles in the metabolism of leucine and ketone body formation.
Specifications
Form
Liquid
Additional notes
ab93747 is purified using conventional chromatography techniques.
General info
Function
Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway (PubMed : 7640268). To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA (PubMed : 7640268).
Sequence similarities
Belongs to the acyl-CoA dehydrogenase family.
Subcellular localisation
Mitochondrion matrix
Target data
Complementary Products
Product promise
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