Recombinant Human IZUMO4 protein is a Human Full Length protein, in the 16 to 214 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
>95% SDS-PAGE
< 1 EU/µg
HEK 293 cells
Fc tag C-Terminus
SDS-PAGE, HPLC
No
H G C L H C H S N F S K K F S F Y R H H V N F K S W W V G D I P V S G A L L T D W S D D T M K E L H L A I P A K I T R E K L D Q V A T A V Y Q M M D Q L Y Q G K M Y F P G Y F P N E L R N I F R E Q V H L I Q N A I I E S R I D C Q H R C G I F Q Y E T I S C N N C T D S H V A C F G Y N C E S S A Q W K S A V Q G L L N Y I N N W H K Q D T S M S L V S P A L R C L E P P H L A N L T L E D A A E C L K Q H V D D I E G R M D E P K S C D K T H T C P P C P A P E L L G G P S V F L F P P K P K D T L M I S R T P E V T C V V V D V S H E D P E V K F N W Y V D G V E V H N A K T K P R E E Q Y N S T Y R V V S V L T V L H Q D W L N G K E Y K C K V S N K A L P A P I E K T I S K A K G Q P R E P Q V Y T L P P S R E E M T K N Q V S L T C L V K G F Y P S D I A V E W E S N G Q P E N N Y K T T P P V L D S D G S F F L Y S K L T V D K S R W Q Q G N V F S C S V M H E A L H N H Y T Q K S L S L S P G K
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
C19orf36, UNQ831/PRO1758, IZUMO4, Izumo sperm-egg fusion protein 4, Sperm 22 kDa protein c113
Recombinant Human IZUMO4 protein is a Human Full Length protein, in the 16 to 214 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
>95% SDS-PAGE
< 1 EU/µg
HEK 293 cells
Fc tag C-Terminus
SDS-PAGE, HPLC
No
No
Human
Reconstitute in PBS
pH: 7.4
Constituents: 99% Phosphate Buffer, 0.87% Sodium chloride
H G C L H C H S N F S K K F S F Y R H H V N F K S W W V G D I P V S G A L L T D W S D D T M K E L H L A I P A K I T R E K L D Q V A T A V Y Q M M D Q L Y Q G K M Y F P G Y F P N E L R N I F R E Q V H L I Q N A I I E S R I D C Q H R C G I F Q Y E T I S C N N C T D S H V A C F G Y N C E S S A Q W K S A V Q G L L N Y I N N W H K Q D T S M S L V S P A L R C L E P P H L A N L T L E D A A E C L K Q H V D D I E G R M D E P K S C D K T H T C P P C P A P E L L G G P S V F L F P P K P K D T L M I S R T P E V T C V V V D V S H E D P E V K F N W Y V D G V E V H N A K T K P R E E Q Y N S T Y R V V S V L T V L H Q D W L N G K E Y K C K V S N K A L P A P I E K T I S K A K G Q P R E P Q V Y T L P P S R E E M T K N Q V S L T C L V K G F Y P S D I A V E W E S N G Q P E N N Y K T T P P V L D S D G S F F L Y S K L T V D K S R W Q Q G N V F S C S V M H E A L H N H Y T Q K S L S L S P G K
Full Length
50 kDa
16 to 214
Recombinant
Fc tag C-Terminus
Lyophilized
Purity greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Belongs to the Izumo family.
Blue Ice
A few weeks
-20°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
IZUMO4 also known as IZUMO family member 4 plays a significant role in sperm-egg fusion during fertilization. This protein with a mass of approximately 35 kDa is part of the IZUMO family known for its function in gamete fusion. IZUMO4 is expressed mainly in the testes specifically on the sperm surface. It is a membrane protein that contributes to the recognition and binding processes essential for successful fertilization.
Proteins like IZUMO4 facilitate the fusion of sperm and egg cells. Researchers have identified IZUMO4 as part of a set of proteins required for the initial stages of fertilization acting in concert with other IZUMO family members. Although not part of a well-defined complex IZUMO4 likely interacts with key proteins on the egg surface to enable membrane fusion marking its important role in reproductive biology.
Proteins like IZUMO4 fit into the fertilization pathway critical for reproductive success. This pathway involves the signaling and interactions necessary for the fusion of sperm and egg. IZUMO4 interacts with other IZUMO proteins and is thought to work closely with JUNO a receptor on the egg surface to facilitate this process. These interactions are essential in the cascade of events leading up to and including fertilization.
Disruptions in proteins such as IZUMO4 can lead to reproductive issues particularly infertility. Infertility related to dysfunction in IZUMO4 may arise when sperm cannot properly bind or fuse with the egg. Researchers also examine its connection with other reproductive proteins and their roles in fertility. Investigating IZUMO4 and related proteins could provide insights into potential targets for treating infertility.
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