Skip to main content

Recombinant Human IZUMO4 protein is a Human Full Length protein, in the 16 to 214 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.

Be the first to review this product! Submit a review

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag C-Terminus

Applications

SDS-PAGE, HPLC

Biologically active

No

Amino acid sequence

H G C L H C H S N F S K K F S F Y R H H V N F K S W W V G D I P V S G A L L T D W S D D T M K E L H L A I P A K I T R E K L D Q V A T A V Y Q M M D Q L Y Q G K M Y F P G Y F P N E L R N I F R E Q V H L I Q N A I I E S R I D C Q H R C G I F Q Y E T I S C N N C T D S H V A C F G Y N C E S S A Q W K S A V Q G L L N Y I N N W H K Q D T S M S L V S P A L R C L E P P H L A N L T L E D A A E C L K Q H V D D I E G R M D E P K S C D K T H T C P P C P A P E L L G G P S V F L F P P K P K D T L M I S R T P E V T C V V V D V S H E D P E V K F N W Y V D G V E V H N A K T K P R E E Q Y N S T Y R V V S V L T V L H Q D W L N G K E Y K C K V S N K A L P A P I E K T I S K A K G Q P R E P Q V Y T L P P S R E E M T K N Q V S L T C L V K G F Y P S D I A V E W E S N G Q P E N N Y K T T P P V L D S D G S F F L Y S K L T V D K S R W Q Q G N V F S C S V M H E A L H N H Y T Q K S L S L S P G K

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Application

HPLC

Reactivity

Reacts

Dilution info

-

Notes

-

Alternative names

Recommended products

Recombinant Human IZUMO4 protein is a Human Full Length protein, in the 16 to 214 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Applications

SDS-PAGE, HPLC

Accession
Q1ZYL8-1
Animal free

No

Species

Human

Reconstitution

Reconstitute in PBS

Concentration
Loading...
Storage buffer

pH: 7.4
Constituents: 99% Phosphate Buffer, 0.87% Sodium chloride

Sequence info

Amino acid sequence

H G C L H C H S N F S K K F S F Y R H H V N F K S W W V G D I P V S G A L L T D W S D D T M K E L H L A I P A K I T R E K L D Q V A T A V Y Q M M D Q L Y Q G K M Y F P G Y F P N E L R N I F R E Q V H L I Q N A I I E S R I D C Q H R C G I F Q Y E T I S C N N C T D S H V A C F G Y N C E S S A Q W K S A V Q G L L N Y I N N W H K Q D T S M S L V S P A L R C L E P P H L A N L T L E D A A E C L K Q H V D D I E G R M D E P K S C D K T H T C P P C P A P E L L G G P S V F L F P P K P K D T L M I S R T P E V T C V V V D V S H E D P E V K F N W Y V D G V E V H N A K T K P R E E Q Y N S T Y R V V S V L T V L H Q D W L N G K E Y K C K V S N K A L P A P I E K T I S K A K G Q P R E P Q V Y T L P P S R E E M T K N Q V S L T C L V K G F Y P S D I A V E W E S N G Q P E N N Y K T T P P V L D S D G S F F L Y S K L T V D K S R W Q Q G N V F S C S V M H E A L H N H Y T Q K S L S L S P G K

Accession

Q1ZYL8

Protein length

Full Length

Predicted molecular weight

50 kDa

Amino acids

16 to 214

Nature

Recombinant

Tags

Fc tag C-Terminus

Specifications

Form

Lyophilized

Additional notes

Purity greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

General info

Sequence similarities

Belongs to the Izumo family.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

A few weeks

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

IZUMO4 also known as IZUMO family member 4 plays a significant role in sperm-egg fusion during fertilization. This protein with a mass of approximately 35 kDa is part of the IZUMO family known for its function in gamete fusion. IZUMO4 is expressed mainly in the testes specifically on the sperm surface. It is a membrane protein that contributes to the recognition and binding processes essential for successful fertilization.

Biological function summary

Proteins like IZUMO4 facilitate the fusion of sperm and egg cells. Researchers have identified IZUMO4 as part of a set of proteins required for the initial stages of fertilization acting in concert with other IZUMO family members. Although not part of a well-defined complex IZUMO4 likely interacts with key proteins on the egg surface to enable membrane fusion marking its important role in reproductive biology.

Pathways

Proteins like IZUMO4 fit into the fertilization pathway critical for reproductive success. This pathway involves the signaling and interactions necessary for the fusion of sperm and egg. IZUMO4 interacts with other IZUMO proteins and is thought to work closely with JUNO a receptor on the egg surface to facilitate this process. These interactions are essential in the cascade of events leading up to and including fertilization.

Associated diseases and disorders

Disruptions in proteins such as IZUMO4 can lead to reproductive issues particularly infertility. Infertility related to dysfunction in IZUMO4 may arise when sperm cannot properly bind or fuse with the egg. Researchers also examine its connection with other reproductive proteins and their roles in fertility. Investigating IZUMO4 and related proteins could provide insights into potential targets for treating infertility.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

0 product images

    Downloads

    Product protocols

    For this product, it's our understanding that no specific protocols are required. You can:

    Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

    For licensing inquiries, please contact partnerships@abcam.com