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AB276521

Recombinant Human IZUMO4 protein (Fc Chimera)

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Recombinant Human IZUMO4 protein (Fc Chimera) is a Human Fragment protein, in the 1 to 214 aa range, expressed in HEK 293 cells, with >96%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

C19orf36, UNQ831/PRO1758, IZUMO4, Izumo sperm-egg fusion protein 4, Sperm 22 kDa protein c113

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SDS-PAGE - Recombinant Human IZUMO4 protein (Fc Chimera) (AB276521)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human IZUMO4 protein (Fc Chimera) (AB276521)

SDS-PAGE analysis of ab276521

Key facts

Purity

>96% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q1ZYL8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MALLLCLVCLTAALAHGCLHCHSNFSKKFSFYRHHVNFKSWWVGDIPVSGALLTDWSDDTMKELHLAIPAKITREKLDQVATAVYQMMDQLYQGKMYFPGYFPNELRNIFREQVHLIQNAIIESRIDCQHRCGIFQYETISCNNCTDSHVACFGYNCESSAQWKSAVQGLLNYINNWHKQDTSMRPRSSAFSWPGTHRATPAFLVSPALRCLEP","proteinLength":"Fragment","predictedMolecularWeight":"49.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":214,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q1ZYL8","tags":[{"tag":"Fc","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IZUMO4 also known as IZUMO family member 4 plays a significant role in sperm-egg fusion during fertilization. This protein with a mass of approximately 35 kDa is part of the IZUMO family known for its function in gamete fusion. IZUMO4 is expressed mainly in the testes specifically on the sperm surface. It is a membrane protein that contributes to the recognition and binding processes essential for successful fertilization.
Biological function summary

Proteins like IZUMO4 facilitate the fusion of sperm and egg cells. Researchers have identified IZUMO4 as part of a set of proteins required for the initial stages of fertilization acting in concert with other IZUMO family members. Although not part of a well-defined complex IZUMO4 likely interacts with key proteins on the egg surface to enable membrane fusion marking its important role in reproductive biology.

Pathways

Proteins like IZUMO4 fit into the fertilization pathway critical for reproductive success. This pathway involves the signaling and interactions necessary for the fusion of sperm and egg. IZUMO4 interacts with other IZUMO proteins and is thought to work closely with JUNO a receptor on the egg surface to facilitate this process. These interactions are essential in the cascade of events leading up to and including fertilization.

Disruptions in proteins such as IZUMO4 can lead to reproductive issues particularly infertility. Infertility related to dysfunction in IZUMO4 may arise when sperm cannot properly bind or fuse with the egg. Researchers also examine its connection with other reproductive proteins and their roles in fertility. Investigating IZUMO4 and related proteins could provide insights into potential targets for treating infertility.
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Specifications

Form

Lyophilized

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General info

Sequence similarities

Belongs to the Izumo family.

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Product protocols

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Target data

See full target information IZUMO4
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Product promise

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