Recombinant Human Jagged 2/JAG2 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Jagged 2 (JAG2) also known as JAGGED 2 is a membrane-bound ligand that weighs about 135 kDa. It interacts with the Notch family receptors to initiate signaling events that regulate cell fate decisions. JAG2 expresses in various tissues with high levels in neural hematopoietic and muscular systems. Its mechanical function involves binding to the Notch receptor on adjacent cells facilitating proteolytic cleavage and activation of the receptor's intracellular domain which then translocates to the nucleus to influence gene expression.

Biological function summary

The JAG2 protein plays a significant role in development and differentiation processes. It acts as a ligand in the Notch signaling pathway which includes other ligands like Jagged 1 (JAG1) and Delta-like proteins. In this complex JAG2 modulates neurogenesis myogenesis and angiogenesis. By affecting these processes JAG2 contributes to tissue homeostasis and the regulation of stem cells.

Pathways

The Notch signaling pathway involving JAG2 plays an important role in cell-cell communication. JAG2 activity in this pathway impact pathways like T-cell development and bone remodeling. It interacts with proteins like Notch1 and RBP-Jκ forming a pivotal part of the regulatory circuit that manages cell differentiation and proliferation.

Researchers link JAG2 to various conditions notably cancer and skeletal disorders. Dysregulation of JAG2 in the Notch pathway can contribute to oncogenesis with increased JAG2 expression observed in certain breast cancers. Additionally interactions between JAG2 and the Notch receptors influence bone diseases as alterations in signaling affect bone density and structure. Understanding the role of JAG2 and related proteins in these pathways allows potential therapeutic targeting in these conditions.