Recombinant Human JMJD7 protein (His tag N-Terminus)
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Recombinant Human JMJD7 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 316 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7, JmjC domain-containing protein 7, Jumonji domain-containing protein 7, L-lysine (3S)-hydroxylase JMJD7, JMJD7
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human JMJD7 protein (His tag N-Terminus) (AB174553)
15% SDS-PAGE analysis of ab174553 (3 μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
JMJD7 is involved in transcriptional regulation modifying histone marks to impact gene expression patterns. It acts as a part of a larger protein complex that includes other histone modifiers. Through its enzymatic activity JMJD7 removes methyl groups from specific lysine residues on histone proteins affecting chromatin structure and accessibility. Its function is important for cellular processes such as differentiation and proliferation which depend on dynamic chromatin states for the regulation of key genes.
Pathways
JMJD7 plays a role in epigenetic regulation and gene expression pathways. It is associated with the histone modification pathway working alongside other proteins like histone deacetylases (HDACs) and lysine demethylases (KDMs). These interactions with proteins such as HDACs and KDMs highlight JMJD7's involvement in coordinating chromatin remodeling which is essential for activating or repressing transcription. Therefore JMJD7 is tightly linked to pathways that determine cell identity and response to environmental cues.
Specifications
Form
Liquid
Additional notes
ab174553 is purified using conventional chromatography techniques.
General info
Function
Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase (PubMed : 28847961, PubMed : 29915238). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed : 28847961). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4 (PubMed : 28847961). After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed : 28847961). Additionally, may play a role in protein biosynthesis by modifying the translation machinery (PubMed : 29915238). Acts as a Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) (PubMed : 29915238).
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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