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AB183230

Recombinant Human JTB protein (His tag N-Terminus)

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Recombinant Human JTB protein (His tag N-Terminus) is a Human Fragment protein, in the 31 to 105 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

HSPC222, JTB, Protein JTB, Jumping translocation breakpoint protein, Prostate androgen-regulated protein, PAR protein

1 Images
SDS-PAGE - Recombinant Human JTB protein (His tag N-Terminus) (AB183230)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human JTB protein (His tag N-Terminus) (AB183230)

15% SDS-PAGE analysis of ab183230 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

O76095

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSEAPVQEEKLSASTSNLPCWLVEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSALMEQRL","proteinLength":"Fragment","predictedMolecularWeight":"10.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":105,"aminoAcidStart":31,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O76095","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

JTB also known as Jumping Translocation Breakpoint is a protein with a molecular mass of approximately 14 kDa. It is expressed widely in a variety of tissues with higher levels seen in certain cancers. Mechanically JTB interacts with several cellular structures and its role in the regulation of cell growth and apoptosis has been observed. This protein often localizes to the mitochondria which hints towards its involvement in energy and metabolic processes.
Biological function summary

The JTB protein plays an important role in promoting cell proliferation and survival. It is part of the transmembrane protein complex and is sometimes involved in cellular signaling pathways that manage these processes. Its activity impacts cellular responses to external stress and can contribute to the regulation of cell cycle progression. These roles are consistent with the observed overexpression of JTB in cancerous cells indicating its function in maintaining cell viability.

Pathways

JTB is involved in several signaling pathways that regulate fundamental cellular activities. It is prominently linked with the PI3K/Akt pathway a critical pathway for cell growth and survival. Through this pathway JTB interacts with Akt a significant protein that facilitates cell growth and proliferation. Another connection lies with the MAPK pathway where JTB interacts with key components that influence cell division and differentiation.

Several studies show that JTB has a notable impact on cancer progression particularly in prostate and colorectal cancers. JTB overexpression often correlates with poor prognosis in these cancers aligning with its role in promoting cell proliferation. Additionally JTB's interaction with caspases proteins essential for apoptosis ties it to disorders involving defective apoptosis such as cancer. Understanding these interactions can help target therapies that modulate JTB function and offer new treatment strategies.
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Specifications

Form

Liquid

Additional notes

ab183230 was purified using conventional chromatography techniques.

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General info

Function

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).

Sequence similarities

Belongs to the JTB family.

Subcellular localisation

Mitochondrion

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Product protocols

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Target data

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
See full target information JTB
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