Recombinant Human JunB protein is a Human Full Length protein, in the 1 to 347 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M C T K M E Q P F Y H D D S Y T A T G Y G R A P G G L S L H D Y K L L K P S L A V N L A D P Y R S L K A P G A R G P G P E G G G G G S Y F S G Q G S D T G A S L K L A S S E L E R L I V P N S N G V I T T T P T P P G Q Y F Y P R G G G S G G G A G G A G G G V T E E Q E G F A D G F V K A L D D L H K M N H V T P P N V S L G A T G G P P A G P G G V Y A G P E P P P V Y T N L S S Y S P A S A S S G G A G A A V G T G S S Y P T T T I S Y L P H A P P F A G G H P A Q L G L G R G A S T F K E E P Q T V P E A R S R D A T P P V S P I N M E D Q E R I K V E R K R L R N R L A A T K C R K R K L E R I A R L E D K V K T L K A E N A G L S S T A G L L R E Q V A Q L K Q K V M T H V S N G C Q L L L G V K G H A F
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity).
Alternative names
Transcription factor JunB, Transcription factor AP-1 subunit JunB, JUNB
Recommended products
Recombinant Human JunB protein is a Human Full Length protein, in the 1 to 347 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P17275-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M C T K M E Q P F Y H D D S Y T A T G Y G R A P G G L S L H D Y K L L K P S L A V N L A D P Y R S L K A P G A R G P G P E G G G G G S Y F S G Q G S D T G A S L K L A S S E L E R L I V P N S N G V I T T T P T P P G Q Y F Y P R G G G S G G G A G G A G G G V T E E Q E G F A D G F V K A L D D L H K M N H V T P P N V S L G A T G G P P A G P G G V Y A G P E P P P V Y T N L S S Y S P A S A S S G G A G A A V G T G S S Y P T T T I S Y L P H A P P F A G G H P A Q L G L G R G A S T F K E E P Q T V P E A R S R D A T P P V S P I N M E D Q E R I K V E R K R L R N R L A A T K C R K R K L E R I A R L E D K V K T L K A E N A G L S S T A G L L R E Q V A Q L K Q K V M T H V S N G C Q L L L G V K G H A F
- Accession
- P17275
- Protein length
- Full Length
- Predicted molecular weight
- 62.3 kDa
- Amino acids
- 1 to 347
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity).
- Sequence similarities
Belongs to the bZIP family. Jun subfamily.
- Post-translational modifications
Ubiquitinated by ITCH, leading to its degradation.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The JunB protein also known as Jun B proto-oncogene is a transcription factor belonging to the AP-1 family. It has a molecular mass of approximately 36 kDa. JunB is expressed in various tissues including epithelial endothelial and immune cells. It often forms heterodimers with other proteins like c-Fos enhancing its capacity to regulate gene expression. Its expression levels can fluctuate with physiological changes and cellular stress indicating its role in managing dynamic cellular processes.
- Biological function summary
JunB influences cell proliferation differentiation and apoptosis. As part of the AP-1 transcription factor complex it binds to specific DNA sequences regulating genes involved in these important processes. This ability to influence cell cycle and immune response highlights the importance of JunB in tissue development and function. Additionally JunB plays a role in controlling the expression of genes involved in inflammatory responses impacting immune cell activation and function.
- Pathways
JunB interacts with various signaling cascades such as the MAPK/ERK and JAK/STAT pathways. These pathways are fundamental in transmitting extracellular signals to the nucleus affecting gene transcription. In the MAPK/ERK pathway JunB works closely with proteins such as c-Jun and c-Fos facilitating cell proliferation and survival. Furthermore it contributes to the JAK/STAT pathway by modulating the inflammatory response demonstrating JunB's adaptability across different cellular contexts.
- Associated diseases and disorders
Altered JunB expression links to conditions like cancer and autoimmune diseases. In some cancers such as leukemia aberrant levels of JunB disrupt normal cell growth collaborating with proteins like c-Myc to promote oncogenesis. In autoimmune disorders JunB can modify immune cell activity through proteins like STAT3 potentially exacerbating inflammation. Understanding JunB functions in these contexts provides insights into potential therapeutic targets for these diseases.
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1 product image
SDS-PAGE - Recombinant Human JunB protein (ab152484)
12.5% SDS-PAGE analysis of ab152484 stained with Coomassie Blue.
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