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AB151894

Recombinant Human K Cadherin/CDH6 protein

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Recombinant Human K Cadherin/CDH6 protein is a Human Fragment protein, in the 22 to 615 aa range, expressed in HEK 293 cells, with >95%, < 0.1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

Cadherin-6, Kidney cadherin, K-cadherin, CDH6

Key facts

Purity

>95% SDS-PAGE

ab151894 is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Lyophilized from a 0.2 µM filtered solution.

Endotoxin level

< 0.1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

P55285

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in PBS

Storage buffer

pH: 7.2 Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

storage-buffer

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Complementary Products

Primary Antibodies

AB133632

Anti-K Cadherin/CDH6 antibody [EPR7394]

RabMAb|Recombinant

Western blot - Anti-K Cadherin/CDH6 antibody [EPR7394] (AB133632)

  • 1
  • 1
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 16
Proteins & Peptides

AB87361

Recombinant Human 14-3-3 zeta protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human 14-3-3 zeta protein (His tag N-Terminus) (AB87361)

  • 0
  • 0
Proteins & Peptides

AB313361

Recombinant Human WFDC2 Protein (His tag)

Mass Spectrometry - Recombinant Human WFDC2 Protein (His tag) (AB313361)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as K Cadherin
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Sequence info

[{"linker":null,"sequence":"TLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGAVDHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"67.44 kDa","actualMolecularWeight":null,"aminoAcidEnd":615,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P55285","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

K Cadherin also known as CDH6 K-Cadherin or Cadherin-6 is a protein that plays a significant mechanical role in cell adhesion. It belongs to the cadherin superfamily of proteins which are known for their role in calcium-dependent cell-cell adhesion. The CDH6 protein has an approximate molecular mass of 88 kDa. It is mainly expressed in the kidney brain and pancreas where it contributes to maintaining proper cellular architecture and signaling.
Biological function summary

Cadherin-6 is involved in the dynamic regulation of tissue morphogenesis and neural development. It interacts with intracellular catenins to form a cadherin-catenin complex which links to the actin cytoskeleton. This complex is essential for transmitting mechanical signals and maintaining cellular structure. CDH6 plays a critical role in branching morphogenesis and neuronal connectivity aiding in the formation of organized tissue architecture and neural networks.

Pathways

Cadherin-6 is a component of the Wnt signaling pathway which influences cell fate determination and patterning. CDH6 interacts with related proteins like beta-catenin facilitating the transduction of signals within the Wnt pathway. Additionally it is part of the epithelial-mesenchymal transition (EMT) pathway where it influences cell migration and differentiation by interacting with growth factor receptors and downstream signaling molecules.

Dysregulation of cadherin-6 expression links to various cancers such as renal cell carcinoma and glioblastoma. In these contexts altered CDH6 levels can impact tumor progression and metastatic potential. Furthermore its interplay with proteins like E-cadherin and integrins affects cellular proliferation and invasion highlighting the importance of CDH6 in cancer biology.
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General info

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

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Product protocols

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Target data

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
See full target information CDH6
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Product promise

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