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AB151628

Recombinant Human Kallikrein 10/K10 protein

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Recombinant Human Kallikrein 10/K10 protein is a Human Full Length protein, in the 31 to 276 aa range, expressed in HEK 293 cells, with >95%, > 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

NES1, PRSSL1, KLK10, Kallikrein-10, Normal epithelial cell-specific 1, Protease serine-like 1

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

> 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

O43240

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.88% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Primary Antibodies

AB273878

Anti-Kallikrein 10/K10 antibody [EPR23573-107]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Kallikrein 10
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Sequence info

[{"linker":null,"sequence":"AEAALLPQNDTRLDPEAYGAPCARGSQPWQVSLFNGLSFHCAGVLVDQSWVLTAAHCGNKPLWARVGDDHLLLLQGEQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLMLLKLARPVVPGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITILSPKECEVFYPGVVTNNMICAGLDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSNVDHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"28 kDa","actualMolecularWeight":null,"aminoAcidEnd":276,"aminoAcidStart":31,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O43240","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Kallikrein 10 also known as KLK10 or serine protease 20 is a protein known for its enzymatic activity. It has a mass of approximately 30 kDa and expresses highly in tissues like the pancreas kidney and hormonal dependent tissues such as the prostate and breast. KLK10 involves in the degradation of extracellular matrix components functioning as a serine protease. Its expression in hormone-responsive tissues indicates a potential role in processes like tissue remodeling and regulation.
Biological function summary

Kallikrein 10 is part of a larger family of serine proteases involved in various physiological processes. These proteases participate in tissue homeostasis and in some instances immune response. KLK10 expression links to cell proliferation and survival potentially influencing cancer progression. The network of serine proteases forms a proteolytic cascade where multiple proteases sequentially activate amplifying the biological responses.

Pathways

Kallikrein 10 plays a critical role in the proteolytic cascade responsible for regulating homeostatic processes. It participates notably in pathways such as the kallikrein-kinin system and the regulation of tumor microenvironment. KLK10 interacts with other kallikreins like KLK5 and KLK6 mediating their activation and functioning in tissue remodeling and repair processes.

Kallikrein 10 has a significant association with cancers and inflammatory conditions. Altered KLK10 expression shows correlation with prostate cancer and breast cancer where it might serve as a biomarker for diagnosis or prognosis. KLK10's involvement with proteins like KLK3 (PSA) in prostate cancer reflects its potential utility in therapeutic strategies especially concerning hormone-dependent tumors.
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Specifications

Form

Liquid

Additional notes

ab151628 is greater than 95% pure as determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Function

Has a tumor-suppressor role for NES1 in breast and prostate cancer.

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

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Product protocols

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Target data

Has a tumor-suppressor role for NES1 in breast and prostate cancer.
See full target information KLK10
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Product promise

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