Recombinant Human Kallikrein 5 protein (denatured) is a Human Fragment protein, in the 67 to 293 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S H M I I N G S D C D M H T Q P W Q A A L L L R P N Q L Y C G A V L V H P Q W L L T A A H C R K K V F R V R L G H Y S L S P V Y E S G Q Q M F Q G V K S I P H P G Y S H P G H S N D L M L I K L N R R I R P T K D V R P I N V S S H C P S A G T K C L V S G W G T T K S P Q V H F P K V L Q C L N I S V L S Q K R C E D A Y P R Q I D D T M F C A G D K A G R D S C Q G D S G G P V V C N G S L Q G L V S W G D Y P C A R P N R P G V Y T N L C K F T K W I Q E T I Q A N S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Alternative names
SCTE, UNQ570/PRO1132, KLK5, Kallikrein-5, Kallikrein-like protein 2, Stratum corneum tryptic enzyme, KLK-L2
Recommended products
Recombinant Human Kallikrein 5 protein (denatured) is a Human Fragment protein, in the 67 to 293 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9Y337-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 12.01% Urea, 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S H M I I N G S D C D M H T Q P W Q A A L L L R P N Q L Y C G A V L V H P Q W L L T A A H C R K K V F R V R L G H Y S L S P V Y E S G Q Q M F Q G V K S I P H P G Y S H P G H S N D L M L I K L N R R I R P T K D V R P I N V S S H C P S A G T K C L V S G W G T T K S P Q V H F P K V L Q C L N I S V L S Q K R C E D A Y P R Q I D D T M F C A G D K A G R D S C Q G D S G G P V V C N G S L Q G L V S W G D Y P C A R P N R P G V Y T N L C K F T K W I Q E T I Q A N S
- Accession
- Q9Y337
- Protein length
- Fragment
- Predicted molecular weight
- 27.8 kDa
- Amino acids
- 67 to 293
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
May be involved in desquamation.
- Sequence similarities
Belongs to the peptidase S1 family. Kallikrein subfamily.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Kallikrein 5 also known as KLK5 or stratum corneum tryptic enzyme is a serine protease enzyme with a molecular weight of approximately 30 kDa. It is encoded by the KLK5 gene and is part of the kallikrein family. KLK5 is mainly expressed in the skin but also found in other tissues such as the esophagus and breast. The enzyme plays a mechanical role in skin barrier function by processing and activating other kallikreins catalyzing the degradation of corneodesmosomes which are essential for skin desquamation.
- Biological function summary
KLK5 assists in maintaining the skin's outermost layer by regulating the desquamation process. It does not operate in isolation but is an intrinsic part of the kallikrein proteolytic cascade which involves several other kallikrein-related peptidases including KLK7 and KLK14. This cascade ensures proper turnover and shedding of damaged or mature cells from the skin surface playing an important role in skin homeostasis and renewal. It is significant in forming a protective barrier against environmental insults.
- Pathways
KLK5 integrates into the skin barrier and inflammation regulation pathways. Its activity influences the activation of other proteases and signaling molecules involved in skin inflammation and repair processes. Related proteins like protease-activated receptors (PARs) interact with KLK5 mediating downstream signaling that impacts inflammation and tissue remodeling. The cascades involving KLK5 serve as checkpoints in cutaneous homeostasis and immune responses.
- Associated diseases and disorders
KLK5 has an important association with skin conditions like atopic dermatitis and Netherton syndrome. In atopic dermatitis abnormal KLK5 expression leads to compromised skin barrier integrity exacerbating the condition. It also relates to LEKTI (lympho-epithelial Kazal-type related inhibitor) dysfunction in Netherton syndrome where uncontrolled KLK5 activity contributes to severe barrier defects. The interactions between KLK5 and these disorders highlight its role in pathophysiological processes affecting skin health.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human Kallikrein 5 protein (denatured) (ab130017)
15% SDS-PAGE analysis of ab130017 (3 μg).
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com