Recombinant Human KAR protein (GST tag N-Terminus)
Be the first to review this product! Submit a review
|
(0 Publication)
Recombinant Human KAR protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 98 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
View Alternative Names
SDR12C1, HSD17B12, Very-long-chain 3-oxoacyl-CoA reductase, 17-beta-hydroxysteroid dehydrogenase 12, 3-ketoacyl-CoA reductase, Estradiol 17-beta-dehydrogenase 12, Short chain dehydrogenase/reductase family 12C member 1, 17-beta-HSD 12, KAR
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human KAR protein (GST tag N-Terminus) (AB132771)
12.5% SDS-PAGE analysis of ab132771 stained with Coomassie Blue.
Complementary Products
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
KARs participate in mediating excitatory synaptic transmission and are part of a complex with other ion channels and receptors like AMPA and NMDA receptors. They regulate synaptic strength and plasticity which are important for learning and memory processes. Active in both pre- and postsynaptic sites KARs can either enhance or inhibit neurotransmitter release affecting neuronal excitability. Their ability to modulate other neurotransmitter systems highlights their diverse influence on neural circuits.
Pathways
KARs are critical components in the glutamatergic signaling pathway which includes AMPA and NMDA receptors as well. They work closely with these proteins to regulate synaptic plasticity and excitatory neurotransmission. Investigations show the involvement of KARs in the long-term potentiation pathway important for memory encoding. Additionally they overlap with metabotropic glutamate receptors influencing intracellular signaling cascades and calcium dynamics.
Specifications
Form
Liquid
General info
Function
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
Sequence similarities
Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
Target data
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com