Recombinant human KAT6B / MORF protein (Active) is a Human Fragment protein, in the 431 to 2073 aa range, expressed in Baculovirus infected Sf9, with >95% purity and suitable for SDS-PAGE, FuncS.
Images
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Baculovirus infected Sf9 cells
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE, FuncS
- Biologically active
- Yes
Amino acid sequence
T K G L I D G L T K F F T P S P D G R R S R G E I I D F S K H Y R P R K K V S Q K Q S C T S H V L A T G T T Q K L K P P P S S L P P P T P I S G Q S P S S Q K S S T A T S S P S P Q S S S S Q C S V P S L S S L T T N S Q L K A L F D G L S H I Y T T Q G Q S R K K G H P S Y A P P K R M R R K T E L S S T A K S K A H F F G K R D I R S R F I S H S S S S S W G M A R G S I F K A I A H F K R T T F L K K H R M L G R L K Y K V T P Q M G T P S P G K G S L T D G R I K P D Q D D D T E I K I N I K Q E S A D V N V I G N K D V V T E E D L D V F K Q A Q E L S W E K I E C E S G V E D C G R Y P S V I E F G K Y E I Q T W Y S S P Y P Q E Y A R L P K L Y L C E F C L K Y M K S K N I L L R H S K K C G W F H P P A N E I Y R R K D L S V F E V D G N M S K I Y C Q N L C L L A K L F L D H K T L Y Y D V E P F L F Y V L T K N D E K G C H L V G Y F S K E K L C Q Q K Y N V S C I M I M P Q H Q R Q G F G R F L I D F S Y L L S R R E G Q A G S P E K P L S D L G R L S Y L A Y W K S V I L E Y L Y H H H E R H I S I K A I S R A T G M C P H D I A T T L Q H L H M I D K R D G R F V I I R R E K L I L S H M E K L K T C S R A N E L D P D S L R W T P I L I S N A A V S E E E R E A E K E A E R L M E Q A S C W E K E E Q E I L S T R A N S R Q S P A K V Q S K N K Y L H S P E S R P V T G E R G Q L L E L S K E S S E E E E E E E D E E E E E E E E E E E E D E E E E E E E E E E E E E E N I Q S S P P R L T K P Q S V A I K R K R P F V L K K K R G R K R R R I N S S V T T E T I S E T T E V L N E P F D N S D E E R P M P Q L E P T C E I E V E E D G R K P V L R K A F Q H Q P G K K R Q T E E E E G K D N H C F K N A D P C R N N M N D D S S N L K E G S K D N P E P L K C K Q V W P K G T K R G L S K W R Q N K E R K T G F K L N L Y T P P E T P M E P D E Q V T V E E Q K E T S E G K T S P S P I R I E E E V K E T G E A L L P Q E E N R R E E T C A P V S P N T S P G E K P E D D L I K P E E E E E E E E E E E E E E E E E E G E E E E G G G N V E K D P D G A K S Q E K E E P E I S T E K E D S A R L D D H E E E E E E D E E P S H N E D H D A D D E D D S H M E S A E V E K E E L P R E S F K E V L E N Q E T F L D L N V Q P G H S N P E V L M D C G V D L T A S C N S E P K E L A G D P E A V P E S D E E P P P G E Q A Q K Q D Q K N S K E V D T E F K E G N P A T M E I D S E T V Q A V Q S L T Q E S S E Q D D T F Q D C A E T Q E A C R S L Q N Y T R A D Q S P Q I A T T L D D C Q Q S D H S S P V S S V H S H P G Q S V R S V N S P S V P A L E N S Y A Q I S P D Q S A I S V P S L Q N M E T S P M M D V P S V S D H S Q Q V V D S G F S D L G S I E S T T E N Y E N P S S Y D S T M G G S I C G N G S S Q N S C S Y S N L T S S S L T Q S S C A V T Q Q M S N I S G S C S M L Q Q T S I S S P P T C S V K S P Q G C V V E R P P S S S Q Q L A Q C S M A A N F T P P M Q L A E I P E T S N A N I G L Y E R M G Q S D F G A G H Y P Q P S A T F S L A K L Q Q L T N T L I D H S L P Y S H S A A V T S Y A N S A S L S T P L S N T G L V Q L S Q S P H S V P G G P Q A Q A T M T P P P N L T P P P M N L P P P L L Q R N M A A S N I G I S H S Q R L Q T Q I A S K G H I S M R T K S A S L S P A A A T H Q S Q I Y G R S Q T V A M Q G P A R T L T M Q R G M N M S V N L M P A P A Y N V N S V N M N M N T L N A M N G Y S M S Q P M M N S G Y H S N H G Y M N Q T P Q Y P M Q M Q M G M M G T Q P Y A Q Q P M Q T P P H G N M M Y T A P G H H G Y M N T G M S K Q S L N G S Y M R R
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
Alternative names
KIAA0383, MORF, MOZ2, MYST4, KAT6B, Histone acetyltransferase KAT6B, Histone acetyltransferase MOZ2, Monocytic leukemia zinc finger protein-related factor, MYST-4
Recommended products
Recombinant human KAT6B / MORF protein (Active) is a Human Fragment protein, in the 431 to 2073 aa range, expressed in Baculovirus infected Sf9, with >95% purity and suitable for SDS-PAGE, FuncS.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Baculovirus infected Sf9 cells
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE, FuncS
- Biologically active
- Yes
- Biological activity
- The specific activity of ab268697 was 95 nmol/min/mg in an acetyltransferase assay using histone H4 peptide (1-21) as substrate.
- Accession
- Q8WYB5-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.5
Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF
Sequence info
Amino acid sequence
- T K G L I D G L T K F F T P S P D G R R S R G E I I D F S K H Y R P R K K V S Q K Q S C T S H V L A T G T T Q K L K P P P S S L P P P T P I S G Q S P S S Q K S S T A T S S P S P Q S S S S Q C S V P S L S S L T T N S Q L K A L F D G L S H I Y T T Q G Q S R K K G H P S Y A P P K R M R R K T E L S S T A K S K A H F F G K R D I R S R F I S H S S S S S W G M A R G S I F K A I A H F K R T T F L K K H R M L G R L K Y K V T P Q M G T P S P G K G S L T D G R I K P D Q D D D T E I K I N I K Q E S A D V N V I G N K D V V T E E D L D V F K Q A Q E L S W E K I E C E S G V E D C G R Y P S V I E F G K Y E I Q T W Y S S P Y P Q E Y A R L P K L Y L C E F C L K Y M K S K N I L L R H S K K C G W F H P P A N E I Y R R K D L S V F E V D G N M S K I Y C Q N L C L L A K L F L D H K T L Y Y D V E P F L F Y V L T K N D E K G C H L V G Y F S K E K L C Q Q K Y N V S C I M I M P Q H Q R Q G F G R F L I D F S Y L L S R R E G Q A G S P E K P L S D L G R L S Y L A Y W K S V I L E Y L Y H H H E R H I S I K A I S R A T G M C P H D I A T T L Q H L H M I D K R D G R F V I I R R E K L I L S H M E K L K T C S R A N E L D P D S L R W T P I L I S N A A V S E E E R E A E K E A E R L M E Q A S C W E K E E Q E I L S T R A N S R Q S P A K V Q S K N K Y L H S P E S R P V T G E R G Q L L E L S K E S S E E E E E E E D E E E E E E E E E E E E D E E E E E E E E E E E E E E N I Q S S P P R L T K P Q S V A I K R K R P F V L K K K R G R K R R R I N S S V T T E T I S E T T E V L N E P F D N S D E E R P M P Q L E P T C E I E V E E D G R K P V L R K A F Q H Q P G K K R Q T E E E E G K D N H C F K N A D P C R N N M N D D S S N L K E G S K D N P E P L K C K Q V W P K G T K R G L S K W R Q N K E R K T G F K L N L Y T P P E T P M E P D E Q V T V E E Q K E T S E G K T S P S P I R I E E E V K E T G E A L L P Q E E N R R E E T C A P V S P N T S P G E K P E D D L I K P E E E E E E E E E E E E E E E E E E G E E E E G G G N V E K D P D G A K S Q E K E E P E I S T E K E D S A R L D D H E E E E E E D E E P S H N E D H D A D D E D D S H M E S A E V E K E E L P R E S F K E V L E N Q E T F L D L N V Q P G H S N P E V L M D C G V D L T A S C N S E P K E L A G D P E A V P E S D E E P P P G E Q A Q K Q D Q K N S K E V D T E F K E G N P A T M E I D S E T V Q A V Q S L T Q E S S E Q D D T F Q D C A E T Q E A C R S L Q N Y T R A D Q S P Q I A T T L D D C Q Q S D H S S P V S S V H S H P G Q S V R S V N S P S V P A L E N S Y A Q I S P D Q S A I S V P S L Q N M E T S P M M D V P S V S D H S Q Q V V D S G F S D L G S I E S T T E N Y E N P S S Y D S T M G G S I C G N G S S Q N S C S Y S N L T S S S L T Q S S C A V T Q Q M S N I S G S C S M L Q Q T S I S S P P T C S V K S P Q G C V V E R P P S S S Q Q L A Q C S M A A N F T P P M Q L A E I P E T S N A N I G L Y E R M G Q S D F G A G H Y P Q P S A T F S L A K L Q Q L T N T L I D H S L P Y S H S A A V T S Y A N S A S L S T P L S N T G L V Q L S Q S P H S V P G G P Q A Q A T M T P P P N L T P P P M N L P P P L L Q R N M A A S N I G I S H S Q R L Q T Q I A S K G H I S M R T K S A S L S P A A A T H Q S Q I Y G R S Q T V A M Q G P A R T L T M Q R G M N M S V N L M P A P A Y N V N S V N M N M N T L N A M N G Y S M S Q P M M N S G Y H S N H G Y M N Q T P Q Y P M Q M Q M G M M G T Q P Y A Q Q P M Q T P P H G N M M Y T A P G H H G Y M N T G M S K Q S L N G S Y M R R
- Accession
- Q8WYB5
- Protein length
- Fragment
- Amino acids
- 431 to 2073
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
Affinity purified.
General info
- Function
Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
- Sequence similarities
Belongs to the MYST (SAS/MOZ) family.
- Post-translational modifications
Autoacetylated (PubMed:10497217, PubMed:11965546). Autoacetylation at Lys-815 is required for proper function.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
KAT6B also known as MORF is a lysine acetyltransferase that plays an important role in chromatin remodeling by acetylating histone H3 at lysine 23. This modification influences gene expression. KAT6B has a molecular mass of approximately 250 kDa. The protein is expressed widely in various tissues including the brain and developmental tissues where it modulates several gene regulatory processes by altering chromatin structure.
- Biological function summary
KAT6B is a part of the Moz Ybf2/Sas3 Sas2 and Tip60 (MYST) family which is a group of acetyltransferases known for their involvement in gene transcription regulation. KAT6B forms a complex with other proteins such as BRPF1 which acts as a scaffold protein to enhance its acetyltransferase activity. This complex plays an important role in cellular differentiation processes and maintenance of gene expression patterns important for development.
- Pathways
KAT6B interacts with key regulatory mechanisms that include the Wnt signaling pathway and the transcriptional regulation by TP53. Within these pathways KAT6B influences gene transcription and cell cycle progression. It also cooperates with proteins like KAT6A another member of the MYST family sharing similar functions in the regulation of gene expression. Their coordinated activity is essential for normal cell function growth and prevention of unregulated cell proliferation.
- Associated diseases and disorders
Alterations in KAT6B function or expression associate with developmental disorders including Say-Barber-Biesecker-Young-Simpson syndrome also known as genitopatellar syndrome. These disorders often involve mutations that disrupt normal acetyltransferase activity leading to developmental abnormalities. KAT6B has a connection with other MYST family proteins such as KAT5 contributing to similar phenotypic outcomes when mutated. Understanding KAT6B's role in these disorders provides insights into potential therapeutic targets for treatment.
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2 product images
Functional Studies - Recombinant human KAT6B / MORF protein (Active) (ab268697)
The specific activity of ab268697 was 95 nmol/min/mg in an acetyltransferase assay using histone H4 peptide (1-21) as substrate.
SDS-PAGE - Recombinant human KAT6B / MORF protein (Active) (ab268697)
SDS-PAGE analysis of ab268697.
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