AB268697

Recombinant human KAT6B / MORF protein (Active)

Name: Recombinant human KAT6B / MORF protein (Active) (ab268697) | Abcam
Brand: Abcam Limited
SKU: AB268697

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Recombinant human KAT6B / MORF protein (Active) is a Human Fragment protein, in the 431 to 2073 aa range, expressed in Baculovirus infected Sf9 cells, with >95%, suitable for SDS-PAGE, FuncS.

View Alternative Names

KIAA0383, MORF, MOZ2, MYST4, KAT6B, Histone acetyltransferase KAT6B, Histone acetyltransferase MOZ2, Monocytic leukemia zinc finger protein-related factor, MYST-4

2 Images

Functional Studies - Recombinant human KAT6B / MORF protein (Active) (AB268697)

FuncS

Supplier Data

Functional Studies - Recombinant human KAT6B / MORF protein (Active) (AB268697)

The specific activity of ab268697 was 95 nmol/min/mg in an acetyltransferase assay using histone H4 peptide (1-21) as substrate.

SDS-PAGE - Recombinant human KAT6B / MORF protein (Active) (AB268697)

SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human KAT6B / MORF protein (Active) (AB268697)

SDS-PAGE analysis of ab268697.

Key facts

Purity

>95% SDS-PAGE

Expression system

Baculovirus infected Sf9 cells

Applications

SDS-PAGE, FuncS

applications

Biologically active

Yes

Biological activity

The specific activity of ab268697 was 95 nmol/min/mg in an acetyltransferase assay using histone H4 peptide (1-21) as substrate.

Accession

Q8WYB5

Animal free

Carrier free

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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Sequence info

[{"sequence":"TKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATGTTQKLKPPPSSLPPPTPISGQSPSSQKSSTATSSPSPQSSSSQCSVPSLSSLTTNSQLKALFDGLSHIYTTQGQSRKKGHPSYAPPKRMRRKTELSSTAKSKAHFFGKRDIRSRFISHSSSSSWGMARGSIFKAIAHFKRTTFLKKHRMLGRLKYKVTPQMGTPSPGKGSLTDGRIKPDQDDDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLYHHHERHISIKAISRATGMCPHDIATTLQHLHMIDKRDGRFVIIRREKLILSHMEKLKTCSRANELDPDSLRWTPILISNAAVSEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLEPTCEIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNKERKTGFKLNLYTPPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASCNSEPKELAGDPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQESSEQDDTFQDCAETQEACRSLQNYTRADQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRSVNSPSVPALENSYAQISPDQSAISVPSLQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNGSSQNSCSYSNLTSSSLTQSSCAVTQQMSNISGSCSMLQQTSISSPPTCSVKSPQGCVVERPPSSSQQLAQCSMAANFTPPMQLAEIPETSNANIGLYERMGQSDFGAGHYPQPSATFSLAKLQQLTNTLIDHSLPYSHSAAVTSYANSASLSTPLSNTGLVQLSQSPHSVPGGPQAQATMTPPPNLTPPPMNLPPPLLQRNMAASNIGISHSQRLQTQIASKGHISMRTKSASLSPAAATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQMQMGMMGTQPYAQQPMQTPPHGNMMYTAPGHHGYMNTGMSKQSLNGSYMRR","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":2073,"aminoAcidStart":431,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q8WYB5","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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Properties and storage information

Shipped at conditions

Dry Ice

Appropriate short-term storage conditions

-80°C

Appropriate long-term storage conditions

-80°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

True

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KAT6B also known as MORF is a lysine acetyltransferase that plays an important role in chromatin remodeling by acetylating histone H3 at lysine 23. This modification influences gene expression. KAT6B has a molecular mass of approximately 250 kDa. The protein is expressed widely in various tissues including the brain and developmental tissues where it modulates several gene regulatory processes by altering chromatin structure.

Biological function summary

KAT6B is a part of the Moz Ybf2/Sas3 Sas2 and Tip60 (MYST) family which is a group of acetyltransferases known for their involvement in gene transcription regulation. KAT6B forms a complex with other proteins such as BRPF1 which acts as a scaffold protein to enhance its acetyltransferase activity. This complex plays an important role in cellular differentiation processes and maintenance of gene expression patterns important for development.

Pathways

KAT6B interacts with key regulatory mechanisms that include the Wnt signaling pathway and the transcriptional regulation by TP53. Within these pathways KAT6B influences gene transcription and cell cycle progression. It also cooperates with proteins like KAT6A another member of the MYST family sharing similar functions in the regulation of gene expression. Their coordinated activity is essential for normal cell function growth and prevention of unregulated cell proliferation.

Alterations in KAT6B function or expression associate with developmental disorders including Say-Barber-Biesecker-Young-Simpson syndrome also known as genitopatellar syndrome. These disorders often involve mutations that disrupt normal acetyltransferase activity leading to developmental abnormalities. KAT6B has a connection with other MYST family proteins such as KAT5 contributing to similar phenotypic outcomes when mutated. Understanding KAT6B's role in these disorders provides insights into potential therapeutic targets for treatment.

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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Function

Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

Sequence similarities

Belongs to the MYST (SAS/MOZ) family.

Post-translational modifications

Autoacetylated (PubMed:10497217, PubMed:11965546). Autoacetylation at Lys-815 is required for proper function.

Subcellular localisation

Nucleus

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Product protocols

Visit the General protocols
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Target data

See full target information KAT6B

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Product promise

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Recombinant human KAT6B / MORF protein (Active)

Functional Studies - Recombinant human KAT6B / MORF protein (Active) (AB268697)

SDS-PAGE - Recombinant human KAT6B / MORF protein (Active) (AB268697)

Key facts

Purity

Expression system

Tags

Applications

Biologically active

Biological activity

Accession

Animal free

Carrier free

Species

Storage buffer

Reactivity data

Sequence info

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Specifications

Form

Additional notes

General info

Function

Sequence similarities

Post-translational modifications

Subcellular localisation

Product protocols

Target data

Complementary Products

Proteins & Peptides

Primary Antibodies

Primary Antibodies

Proteins & Peptides

Product promise