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AB183227

Recombinant Human KCNMB3 protein (denatured) (His tag N-Terminus)

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Recombinant Human KCNMB3 protein (denatured) (His tag N-Terminus) is a Human Fragment protein, in the 82 to 207 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

KCNMB2, KCNMBL, KCNMB3, Calcium-activated potassium channel subunit beta-3, BK channel subunit beta-3, Charybdotoxin receptor subunit beta-3, K(VCA)beta-3, Maxi K channel subunit beta-3, Slo-beta-3, BKbeta3, Hbeta3

1 Images
SDS-PAGE - Recombinant Human KCNMB3 protein (denatured) (His tag N-Terminus) (AB183227)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human KCNMB3 protein (denatured) (His tag N-Terminus) (AB183227)

15% SDS-PAGE analysis of ab183227 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NPA1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGTPFSCFYSPASQSEDVILIKKYDQ","proteinLength":"Fragment","predictedMolecularWeight":"16.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":207,"aminoAcidStart":82,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NPA1","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.

Sequence similarities

Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily.

Post-translational modifications

N-glycosylated.. The extracellular domain contains disulfide bond essential for the gating mechanism.

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Product protocols

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Target data

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
See full target information KCNMB3
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Complementary Products

Primary Antibodies

AB137041

Anti-KCNMB3 antibody [EPR9543(B)]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-KCNMB3 antibody [EPR9543(B)] (AB137041)

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