Recombinant Human KCNMB3 protein (denatured) is a Human Fragment protein, in the 82 to 207 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S K P F M L S I Q R E E S T C T A I H T D I M D D W L D C A F T C G V H C H G Q G K Y P C L Q V F V N L S H P G Q K A L L H Y N E E A V Q I N P K C F Y T P K C H Q D R N D L L N S A L D I K E F F D H K N G T P F S C F Y S P A S Q S E D V I L I K K Y D Q
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
Alternative names
KCNMB2, KCNMBL, KCNMB3, Calcium-activated potassium channel subunit beta-3, BK channel subunit beta-3, Charybdotoxin receptor subunit beta-3, K(VCA)beta-3, Maxi K channel subunit beta-3, Slo-beta-3, BKbeta3, Hbeta3
Recommended products
Recombinant Human KCNMB3 protein (denatured) is a Human Fragment protein, in the 82 to 207 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9NPA1-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S K P F M L S I Q R E E S T C T A I H T D I M D D W L D C A F T C G V H C H G Q G K Y P C L Q V F V N L S H P G Q K A L L H Y N E E A V Q I N P K C F Y T P K C H Q D R N D L L N S A L D I K E F F D H K N G T P F S C F Y S P A S Q S E D V I L I K K Y D Q
- Accession
- Q9NPA1
- Protein length
- Fragment
- Predicted molecular weight
- 16.8 kDa
- Amino acids
- 82 to 207
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
- Sequence similarities
Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily.
- Post-translational modifications
N-glycosylated.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
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Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human KCNMB3 protein (denatured) (ab183227)
15% SDS-PAGE analysis of ab183227 (3μg).
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
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