Recombinant human KDS protein
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Recombinant human KDS protein is a Human Fragment protein, in the 1 to 463 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, WB, FuncS.
View Alternative Names
DPK, JIK, KDS, MAP3K18, TAOK3, Serine/threonine-protein kinase TAO3, Cutaneous T-cell lymphoma-associated antigen HD-CL-09, Dendritic cell-derived protein kinase, JNK/SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from chicken homolog A, Thousand and one amino acid protein 3, CTCL-associated antigen HD-CL-09, hKFC-A
- FuncS
Unknown
Functional Studies - Recombinant human KDS protein (AB125551)
The specific activity of ab125551 was determined to be 260 nmol/min/mg.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human KDS protein (AB125551)
SDS-PAGE analysis of ab125551.
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![Western blot - Anti-KDS antibody [EPR4947(2)] (AB150388)](https://content.abcam.com/products/images/kds-antibody-epr49472-ab150388--western-blot-img104935.jpg)
Reactivity data
Product details
ab204875 (PKC epsilon peptide) can be utilized as a substrate for assessing kinase activity
This product was previously labelled as TAOK3
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Specifications
Form
Liquid
Additional notes
Assessed by densitometry.
General info
Function
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells (PubMed : 30373850). Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed : 38166031). Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells (By similarity). Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells (By similarity). Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway (PubMed : 32807497). Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed : 34634521). Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines (By similarity). Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue (By similarity).
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Post-translational modifications
Autophosphorylated (PubMed:10559204). Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade (PubMed:17396146). Phosphorylated at Ser-324 and on Tyr residues during T cell activation (PubMed:30373850). Phosphorylated by LRRK2 (PubMed:20949042).
Target data
Product promise
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