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AB163528

Recombinant Human KIAA1199 protein (GST tag N-Terminus)

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Recombinant Human KIAA1199 protein (GST tag N-Terminus) is a Human Fragment protein, in the 880 to 979 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

HYBID, KIAA1199, CEMIP, Cell migration-inducing and hyaluronan-binding protein, Hyaluronan binding protein involved in hyaluronan depolymerization

1 Images
SDS-PAGE - Recombinant Human KIAA1199 protein (GST tag N-Terminus) (AB163528)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human KIAA1199 protein (GST tag N-Terminus) (AB163528)

ab163528 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q8WUJ3

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Primary Antibodies

AB308291

Anti-KIAA1199 antibody [EPR27442-24] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-KIAA1199 antibody [EPR27442-24] - BSA and Azide free (AB308291)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"LYDGPINIQNCTFRKFVALEGRHTSALAFRLNNAWQSCPHNNVTGIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDVDGSVSEYPGSYLTKNDNW","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":979,"aminoAcidStart":880,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8WUJ3","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.

Sequence similarities

Belongs to the CEMIP family.

Post-translational modifications

N-glycosylated; glycosylation is not necessary for HA-binding.

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Product protocols

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Target data

Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.
See full target information CEMIP
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Product promise

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