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AB164803

Recombinant Human KLC4 protein (GST tag N-Terminus)

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Recombinant Human KLC4 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 619 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KNSL8, KLC4, Kinesin light chain 4, KLC 4, Kinesin-like protein 8

1 Images
SDS-PAGE - Recombinant Human KLC4 protein (GST tag N-Terminus) (AB164803)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human KLC4 protein (GST tag N-Terminus) (AB164803)

ab164803 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9NSK0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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SDS-PAGE - Recombinant Human UCN2/SRP protein (GST tag N-Terminus) (AB164813)

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SDS-PAGE - Recombinant Human TUBA1C protein (GST tag N-Terminus) (AB164660)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSGLVLGQRDEPAGHRLSQEEILGSTRLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHEEGLVHEKARQLRRSMENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQRSEQAVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFPNEEEEDPSNGLSRGQGATAAQQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKPIWMHAEEREEMSKSRHHEGGTPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKLEAAETLEECALRSRRQGTDPISQTKVAELLGESDGRRTSQEGPGDSVKFEGGEDASVAVEWSGDGSGTLQRSGSLGKIRDVLRRSSELLVRKLQGTEPRPSSSNMKRAASLNYLNQPSAAPLQVSRGLSASTMDLSSSS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":619,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9NSK0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Kinesin light chain 4 (KLC4) is an essential component of the kinesin motor protein complex also known as a microtubule-associated protein. The mass of KLC4 is approximately 55 kDa. This protein allows for the transport of organelles and vesicles along microtubules within cells. KLC4 is expressed in various tissues including the brain and heart and plays a role in cellular logistics aiding efficient and directed movement of cellular components.
Biological function summary

Kinesin light chain 4 functions as part of the kinesin-1 complex. It interacts with kinesin heavy chains to mediate cargo binding and transport. This key role involves binding to various cargo adapters and regulatory proteins ensuring proper delivery of materials within cells. By facilitating intracellular trafficking KLC4 supports cellular maintenance and neuron functioning.

Pathways

Kinesin light chain 4 participates in essential intracellular transport processes. Within the broader scope of membrane trafficking pathways KLC4 collaborates with proteins such as kinesin heavy chain and kinesin-associated protein 3. It participates in axonal transport pathways important for the movement of growth factors and neurotransmitters which are critical for neuron signaling and health.

Kinesin light chain 4 links to neuronal disorders. Disruption in the function of KLC4 can contribute to conditions like Alzheimer's disease and amyotrophic lateral sclerosis (ALS). Misregulation of axonal transport involving kinesin light chain 4 and associated proteins can lead to neurodegeneration. Additionally the target's interaction with amyloid precursor protein (APP) in Alzheimer's disease underlines its importance in maintaining neurological health.
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Specifications

Form

Liquid

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General info

Function

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).

Sequence similarities

Belongs to the kinesin light chain family.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).
See full target information KLC4
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