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AB114550

Recombinant Human KLF6 protein

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Recombinant Human KLF6 protein is a Human Fragment protein, in the 1 to 261 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

BCD1, COPEB, CPBP, ST12, KLF6, Krueppel-like factor 6, B-cell-derived protein 1, Core promoter element-binding protein, GC-rich sites-binding factor GBF, Proto-oncogene BCD1, Suppressor of tumorigenicity 12 protein, Transcription factor Zf9

1 Images
SDS-PAGE - Recombinant Human KLF6 protein (AB114550)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human KLF6 protein (AB114550)

12.5% SDS-PAGE Stained with Coomassie Blue showing ab114550

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA, SDS-PAGE

applications

Biologically active

No

Accession

Q99612

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MDVLPMCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDSQEDLWTKIILAREKKEESELKISSSPPEDTLISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLGSSVTSAPPSSPELSREPSQLWGCVPGELPSPGKVRSGTSGKPGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPF","proteinLength":"Fragment","predictedMolecularWeight":"54.71 kDa","actualMolecularWeight":null,"aminoAcidEnd":261,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q99612","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KLF6 also known as Kruppel-like factor 6 is a transcription factor involved in regulating gene expression. It has a molecular weight of approximately 31 kDa. KLF6 distributes in various tissues including the liver lungs and kidneys where it influences cellular growth differentiation and apoptosis. Researchers often identify this factor by its notable zinc finger DNA-binding motif which facilitates its role in controlling target genes' transcription.
Biological function summary

KLF6 influences several cellular processes by acting as a transcriptional activator. It forms part of larger transcriptional complexes that modulate gene expression in response to specific cellular contexts. For instance KLF6 contributes to cell growth regulation by affecting genes involved in the cell cycle and apoptosis. Its function as a tumor suppressor has gained considerable interest for its involvement in cellular responses to damage and repair.

Pathways

KLF6 interacts with different cellular signaling routes to maintain homeostasis. It plays a significant role in the TGF-β signaling pathway which is important for maintaining cell stability and promoting apoptosis. Additionally it associates with the p53 pathway enhancing its ability to suppress tumor formation. Through these interactions KLF6 works alongside proteins such as SMAD3 and p53 to ensure proper regulation of cellular growth and repair.

KLF6 has associations with cancer and fibrotic diseases. Many studies link reduced or altered KLF6 expression to various human cancers such as prostate and colorectal cancers due to its tumor suppressor function. KLF6 also relates to cardiovascular diseases through its influence on genes associated with fibrosis and inflammation. In these contexts it interacts with other proteins like SMAD3 and TGF-β highlighting its role in disease progression and severity.
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Specifications

Form

Liquid

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General info

Function

Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.
See full target information KLF6
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Primary Antibodies

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Primary Antibodies

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