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AB187414

Recombinant Human KLHDC8B protein (denatured) (His tag N-Terminus)

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Recombinant Human KLHDC8B protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 354 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

FP17659, KLHDC8B, Kelch domain-containing protein 8B

1 Images
SDS-PAGE - Recombinant Human KLHDC8B protein (denatured) (AB187414)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human KLHDC8B protein (denatured) (AB187414)

15% SDS-PAGE analysis of ab187414 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8IXV7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSAGGGRAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQGPSQAVEALCLRDGV","proteinLength":"Full Length","predictedMolecularWeight":"40.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":354,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8IXV7","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KLHDC8B also known as Kelch domain-containing protein 8B is a mechanical component in cellular functions. This protein has a mass of approximately 32 kDa. It is expressed in various tissues with particular presence in the brain and reproductive organs. KLHDC8B contains a Kelch motif which is known for facilitating protein-protein interactions making it essential for various intracellular processes.
Biological function summary

KLHDC8B plays a role in maintaining cell shape and integrity through its interactions with other cytoskeletal proteins. It forms part of protein complexes that modulate actin filament dynamics. Besides structural functions KLHDC8B participates in processes related to cell movement and division. It remains active in regions with intense cytoskeletal activity reflecting its functional importance.

Pathways

KLHDC8B integrates into the Wnt signaling and cytoskeletal regulation pathways. Through the Wnt pathway it potentially associates with proteins such as β-catenin which impacts cell proliferation and migration. In cytoskeletal regulation it coordinates with actin and tubulin influencing cellular architecture and transport mechanisms essential for cellular activities.

KLHDC8B has connections to cancers including certain brain tumors and reproductive disorders like infertility. Alterations in KLHDC8B expression can impact cytoskeletal arrangement leading to aberrant cellular growth and division seen in these diseases. Through these associations KLHDC8B links with other proteins such as p53 known for tumor suppressive functions and pathways in cellular stress responses.
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Specifications

Form

Liquid

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General info

Function

Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed : 20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed : 22988245, PubMed : 23713010).

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Product protocols

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Target data

Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed : 20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed : 22988245, PubMed : 23713010).
See full target information KLHDC8B
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