Recombinant Human KLRG1 protein (denatured) (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KLRG1 also known as killer cell lectin-like receptor G1 is a protein with a mass of about 30 kDa. It functions mechanically as an inhibitory receptor on natural killer (NK) cells and subsets of T cells. KLRG1 binds to classical cadherins like E-cadherin and N-cadherin modulating immune cell activity. Expression of KLRG1 is found mainly on mature NK cells and activated T cells particularly on those with an effector memory phenotype. Detecting KLRG1 expression often involves flow cytometry techniques using specific anti-KLRG1 antibodies.

Biological function summary

KLRG1 serves as a modulator of immune responses by delivering inhibitory signals that regulate immune cell cytotoxicity and cytokine production. It is not part of a larger protein complex but interacts with other molecules on the cell surface to perform its role. The engagement of its ligands mediates the reduction of immune responses which is important during chronic infections and cancer to prevent excessive immune activation.

Pathways

Several immune regulatory pathways involve KLRG1. It notably participates in the balance between immune activation and inhibition within the immune system. KLRG1 interacts with signaling pathways such as those regulated by T-cell receptor (TCR) signaling and NK cell activation. Related proteins in these pathways include CD226 and NKG2A which also play a role in determining the immune cell response.

KLRG1 has relevance in chronic infections and cancer due to its role in regulating immune cell activity. In chronic viral infections such as HIV and hepatitis KLRG1 expression is upregulated coinciding with T cell exhaustion. This marker is also significant in cancer where it contributes to the immune evasion mechanisms of tumors. The association with other proteins like PD-1 and TIM-3 further highlights KLRG1's function in these contexts serving as potential targets for therapeutic intervention.