Recombinant human KMT2D / MLL2 protein (Active)
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Recombinant human KMT2D / MLL2 protein (Active) is a Human Fragment protein, in the 5317 to 5537 aa range, expressed in Baculovirus infected Sf9 cells, with >80%, suitable for SDS-PAGE, FuncS.
View Alternative Names
ALR, MLL2, MLL4, KMT2D, Histone-lysine N-methyltransferase 2D, Lysine N-methyltransferase 2D, ALL1-related protein, Myeloid/lymphoid or mixed-lineage leukemia protein 2
- FuncS
Supplier Data
Functional Studies - Recombinant human KMT2D / MLL2 protein (Active) (AB268800)
The specific activity of ab268800 was 2.5 nmol/min/mg in a methyltransferase assay using histone H3 peptide (1-21) as substrate.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human KMT2D / MLL2 protein (Active) (AB268800)
SDS-PAGE analysis of ab268800.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
KMT2D is an important regulatory factor that influences gene expression. It is part of a larger complex that includes other interacting proteins necessary for histone modification. Through its enzymatic activity KMT2D impacts gene transcription by modifying chromatin structure making it more or less accessible for transcription factors to bind DNA. This control over gene expression has implications in development differentiation and cellular response to external stimuli.
Pathways
KMT2D integrates into the broader framework of chromatin modification and transcriptional regulation pathways. It interacts with proteins such as ASH2L and RBBP5 which are components of the COMPASS-like complex playing roles in modifying histones to regulate gene expression dynamically. KMT2D's function intersects particularly with the Hedgehog and Wnt signaling pathways both important for developmental processes and cellular proliferation.
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed : 25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed : 17500065, PubMed : 25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed : 16603732).
Sequence similarities
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
Subcellular localisation
Nucleus
Target data
Complementary Products
Primary Antibodies
AB319036
Anti-KMT2B / MLL4 antibody [EPR27970-7] - C-terminal - BSA and Azide free
Advanced Validation|Recombinant|RabMAb
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Product promise
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