Recombinant Human KMT5C/SUV4-20h2 protein (GST tag N-Terminus)
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Recombinant Human KMT5C/SUV4-20h2 protein (GST tag N-Terminus) is a Human Fragment protein, in the 2 to 280 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
View Alternative Names
SUV420H2, PP7130, KMT5C, Histone-lysine N-methyltransferase KMT5C, Lysine N-methyltransferase 5C, Lysine-specific methyltransferase 5C, Suppressor of variegation 4-20 homolog 2, [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B, [histone H4]-lysine20 N-methyltransferase KMT5B, Su(var)4-20 homolog 2, Suv4-20h2
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human KMT5C/SUV4-20h2 protein (GST tag N-Terminus) (AB80290)
10% SDS-PAGE showing ab80290 at approximately 58kDa (5μg).
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
KMT5C influences chromatin condensation and thereby contributes to genomic stability. The protein often functions as part of larger complexes involved in epigenetic regulation working closely with other chromatin-modifying proteins. By methylating H4K20 KMT5C plays a significant role in regulating cell cycle progression notably during the DNA damage response and repair processes. This function assists in maintaining proper cellular function and preventing aberrant cellular proliferation.
Pathways
KMT5C has significant involvement in the DNA damage repair pathway and the cell cycle regulation. Within these pathways it associates with proteins like 53BP1 an important player in DNA damage recognition and repair. KMT5C activity in histone modification integrates into the broader framework of chromatin remodeling necessary for efficient DNA repair and cell cycle control ensuring cellular maintenance in response to genomic insults.
Specifications
Form
Liquid
General info
Function
Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed : 24396869, PubMed : 28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed : 24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed : 28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).
Sequence similarities
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
Subcellular localisation
Nucleus
Target data
Product promise
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